Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4495115..4495698 Replicon chromosome
Accession NZ_HG938355
Organism Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141

Toxin (Protein)


Gene name PumA Uniprot ID A0A068TF81
Locus tag RG1141_RS21855 Protein ID WP_038548341.1
Coordinates 4495402..4495698 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A068TGX6
Locus tag RG1141_RS21850 Protein ID WP_038548338.1
Coordinates 4495115..4495402 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG1141_RS21825 4491639..4491869 - 231 WP_038548326.1 hypothetical protein -
RG1141_RS21830 4492010..4492288 - 279 WP_157885208.1 hypothetical protein -
RG1141_RS21835 4492301..4492564 - 264 WP_038548331.1 hypothetical protein -
RG1141_RS21840 4492868..4494475 + 1608 WP_038548333.1 exodeoxyribonuclease VII large subunit -
RG1141_RS21845 4494475..4495068 + 594 WP_038548336.1 NAD(P)H-dependent oxidoreductase -
RG1141_RS21850 4495115..4495402 - 288 WP_038548338.1 putative addiction module antidote protein Antitoxin
RG1141_RS21855 4495402..4495698 - 297 WP_038548341.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RG1141_RS21860 4495749..4497002 - 1254 WP_038548344.1 aminopeptidase -
RG1141_RS21865 4497082..4497891 + 810 WP_157885209.1 hypothetical protein -
RG1141_RS21870 4497921..4498808 - 888 WP_038549963.1 MBL fold metallo-hydrolase -
RG1141_RS21875 4498817..4499290 - 474 WP_038548349.1 Cys-tRNA(Pro) deacylase -
RG1141_RS21880 4499307..4499660 - 354 WP_038548352.1 ArsC family reductase -
RG1141_RS32515 4499834..4499998 + 165 WP_173426764.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11079.75 Da        Isoelectric Point: 10.0489

>T285168 WP_038548341.1 NZ_HG938355:c4495698-4495402 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
VFELKQTETFLKWRTRLKDERARALIASRLDRLAFGHAGDVAPVGEGVSELRIHHGPGYRVYFQQRGDILIVLLCGGDKS
SQAKDIKAAKRLAMEWSE

Download         Length: 297 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10109.55 Da        Isoelectric Point: 5.0495

>AT285168 WP_038548338.1 NZ_HG938355:c4495402-4495115 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
MAEKLTVYDPAEDLGSDQAIAAFMAEAFETEDAAYIAHALGVVARAKGMMQIAKDTGLSREQLYRSFSATGNPTLKTTIA
VMKSLGIELTAKAHS

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068TF81

Antitoxin

Source ID Structure
AlphaFold DB A0A068TGX6

References