285151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 672184..672815 Replicon plasmid pHAMBI540a
Accession NZ_HG938354
Organism Neorhizobium galegae bv. orientalis str. HAMBI 540

Toxin (Protein)


Gene name vapC Uniprot ID A0A068SZT5
Locus tag RG540_RS25695 Protein ID WP_041364739.1
Coordinates 672184..672570 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A068SYK7
Locus tag RG540_RS25700 Protein ID WP_040124628.1
Coordinates 672567..672815 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG540_RS25675 667934..668749 - 816 WP_046600622.1 ABC transporter ATP-binding protein -
RG540_RS25680 668806..669831 - 1026 WP_080725073.1 ABC transporter substrate-binding protein -
RG540_RS25685 669970..670854 + 885 WP_041366359.1 helix-turn-helix transcriptional regulator -
RG540_RS25690 670957..671610 + 654 WP_041364737.1 HAD hydrolase-like protein -
RG540_RS32520 672017..672166 - 150 WP_157884686.1 hypothetical protein -
RG540_RS25695 672184..672570 - 387 WP_041364739.1 type II toxin-antitoxin system VapC family toxin Toxin
RG540_RS25700 672567..672815 - 249 WP_040124628.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RG540_RS25705 673362..674363 + 1002 WP_051909790.1 LysR family transcriptional regulator -
RG540_RS25710 674390..675850 + 1461 WP_041366361.1 NAD(P)/FAD-dependent oxidoreductase -
RG540_RS25715 675885..676802 + 918 WP_041366363.1 ABC transporter permease -
RG540_RS25720 676811..677668 + 858 WP_041364741.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ddhA / htpB 1..1807065 1807065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-81)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13969.03 Da        Isoelectric Point: 5.1800

>T285151 WP_041364739.1 NZ_HG938354:c672570-672184 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
MIVDTSALVAILYREPEAARFVKAIHEVELTRISVANYVELSMVVEGQLGLDGMRQAEAFLRRAGIIVEPVTLDHGELAR
QAFLDFGKGRHKAGLNFGDCFAYALAKATGEPLLFKGNDFSQTDVQAA

Download         Length: 387 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9189.45 Da        Isoelectric Point: 8.6090

>AT285151 WP_040124628.1 NZ_HG938354:c672815-672567 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
MSLSIKDPEAHRLAQAISHATGESMTRVVTEALRERFAKIERRKGRASVEELLAIADRAAANVKRPYVDHADFLYDENGL
PK

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068SZT5

Antitoxin

Source ID Structure
AlphaFold DB A0A068SYK7

References