Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-Xre |
| Location | 104849..105725 | Replicon | plasmid pHAMBI540a |
| Accession | NZ_HG938354 | ||
| Organism | Neorhizobium galegae bv. orientalis str. HAMBI 540 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A068T007 |
| Locus tag | RG540_RS23025 | Protein ID | WP_041363854.1 |
| Coordinates | 104849..105364 (-) | Length | 172 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A068SY94 |
| Locus tag | RG540_RS23030 | Protein ID | WP_041363855.1 |
| Coordinates | 105357..105725 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RG540_RS23000 | 100307..100798 | + | 492 | WP_041363849.1 | MarR family transcriptional regulator | - |
| RG540_RS23005 | 100911..101252 | + | 342 | WP_041363850.1 | YciI family protein | - |
| RG540_RS23010 | 101258..102514 | + | 1257 | WP_041363851.1 | DNA-directed RNA polymerase sigma-70 factor | - |
| RG540_RS23015 | 102554..102955 | - | 402 | WP_040123958.1 | response regulator | - |
| RG540_RS23020 | 102967..104697 | - | 1731 | WP_046599294.1 | ATPase | - |
| RG540_RS23025 | 104849..105364 | - | 516 | WP_041363854.1 | RES domain-containing protein | Toxin |
| RG540_RS23030 | 105357..105725 | - | 369 | WP_041363855.1 | DUF2384 domain-containing protein | Antitoxin |
| RG540_RS23035 | 105802..106446 | - | 645 | WP_041363856.1 | SMC-Scp complex subunit ScpB | - |
| RG540_RS23040 | 106449..107399 | - | 951 | WP_080725055.1 | DUF1403 family protein | - |
| RG540_RS23045 | 107634..109148 | + | 1515 | WP_041366231.1 | carboxypeptidase | - |
| RG540_RS23050 | 109270..109992 | + | 723 | WP_041363858.1 | L,D-transpeptidase | - |
| RG540_RS23055 | 110103..110657 | + | 555 | WP_041363859.1 | recombination regulator RecX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ddhA / htpB | 1..1807065 | 1807065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 18581.09 Da Isoelectric Point: 5.5471
>T285148 WP_041363854.1 NZ_HG938354:c105364-104849 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
MPELAPESGILWRAYVPRWAHAPLSGDGAARFGGRWNPVGAATIYAARELCTAWAEYNQGFVQHPALIAQLRLDGARLAD
LTSPQVLAGLGVDETIHHCEWRADLDAGQIPATHLVAERLLDDGCDGVIYPSFMSPGGTCVALWRWNGKDQLKLTVTDPD
GRLPKSPASWL
MPELAPESGILWRAYVPRWAHAPLSGDGAARFGGRWNPVGAATIYAARELCTAWAEYNQGFVQHPALIAQLRLDGARLAD
LTSPQVLAGLGVDETIHHCEWRADLDAGQIPATHLVAERLLDDGCDGVIYPSFMSPGGTCVALWRWNGKDQLKLTVTDPD
GRLPKSPASWL
Download Length: 516 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 12938.96 Da Isoelectric Point: 9.9124
>AT285148 WP_041363855.1 NZ_HG938354:c105725-105357 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
MAHAFEIGAAAFRESQSALLSARRVSDLLGLTQAELAKLIGVARNTLTAKSGARKVDLALSPVVRILAMASEMAGDENRA
AIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA
MAHAFEIGAAAFRESQSALLSARRVSDLLGLTQAELAKLIGVARNTLTAKSGARKVDLALSPVVRILAMASEMAGDENRA
AIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A068T007 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A068SY94 |