Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 765751..766331 | Replicon | chromosome |
Accession | NZ_HG938353 | ||
Organism | Neorhizobium galegae bv. orientalis str. HAMBI 540 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A068SL96 |
Locus tag | RG540_RS03845 | Protein ID | WP_038584771.1 |
Coordinates | 765751..766005 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A068SMA4 |
Locus tag | RG540_RS03850 | Protein ID | WP_038584774.1 |
Coordinates | 766002..766331 (+) | Length | 110 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
RG540_RS03815 | 761048..761890 | + | 843 | WP_038584753.1 | metallophosphoesterase | - |
RG540_RS03820 | 761893..762537 | - | 645 | WP_038584756.1 | ThuA domain-containing protein | - |
RG540_RS03825 | 762634..763323 | - | 690 | WP_038584759.1 | YafY family transcriptional regulator | - |
RG540_RS03830 | 763459..764091 | + | 633 | WP_038584762.1 | LysE family translocator | - |
RG540_RS03835 | 764271..764711 | + | 441 | WP_038584765.1 | cytochrome c | - |
RG540_RS03840 | 764792..765706 | + | 915 | WP_038584768.1 | cytochrome c | - |
RG540_RS03845 | 765751..766005 | + | 255 | WP_038584771.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
RG540_RS03850 | 766002..766331 | + | 330 | WP_038584774.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
RG540_RS03855 | 766348..766845 | - | 498 | WP_038584777.1 | GNAT family N-acetyltransferase | - |
RG540_RS03860 | 767023..767997 | - | 975 | WP_038592995.1 | prolyl aminopeptidase | - |
RG540_RS03865 | 768130..768423 | + | 294 | WP_038584779.1 | hypothetical protein | - |
RG540_RS03870 | 768410..768772 | + | 363 | WP_038584782.1 | hypothetical protein | - |
RG540_RS03875 | 768792..769205 | - | 414 | WP_038541031.1 | helix-turn-helix domain-containing protein | - |
RG540_RS31045 | 769359..769910 | - | 552 | WP_051909231.1 | hypothetical protein | - |
RG540_RS03885 | 770034..770252 | + | 219 | WP_038584785.1 | antitoxin MazE family protein | - |
RG540_RS03890 | 770249..770590 | + | 342 | WP_038584788.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
RG540_RS03895 | 770686..770958 | + | 273 | WP_038584791.1 | Ni(II)/Co(II)-sensing transcriptional repressor DmeR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9594.04 Da Isoelectric Point: 9.8829
>T285141 WP_038584771.1 NZ_HG938353:765751-766005 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
MNSKQRKTLGAIFRDPVSPSIDWSDVENLLIAIGCRLLEGNGSRVRFEKDGLVAFFHRPHPDKEAKRYQIKDARLFLSQL
GIEP
MNSKQRKTLGAIFRDPVSPSIDWSDVENLLIAIGCRLLEGNGSRVRFEKDGLVAFFHRPHPDKEAKRYQIKDARLFLSQL
GIEP
Download Length: 255 bp
Antitoxin
Download Length: 110 a.a. Molecular weight: 11877.32 Da Isoelectric Point: 4.9230
>AT285141 WP_038584774.1 NZ_HG938353:766002-766331 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
MNVLEYKGYSARIEFDAEDEIFVGHIAGIADVVGFHADSVADLKTAFHEAVDDYLETCERLGRSPHKPYSGRVMFRIDPD
VHARAAKAAELAGKSLNEWAGEVLAKAAG
MNVLEYKGYSARIEFDAEDEIFVGHIAGIADVVGFHADSVADLKTAFHEAVDDYLETCERLGRSPHKPYSGRVMFRIDPD
VHARAAKAAELAGKSLNEWAGEVLAKAAG
Download Length: 330 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A068SL96 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A068SMA4 |