Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5367103..5367742 Replicon chromosome
Accession NZ_HG917972
Organism Mycobacterium marinum E11

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A2Z5YL42
Locus tag MMARE11_RS22015 Protein ID WP_020729617.1
Coordinates 5367103..5367549 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID B2HEJ8
Locus tag MMARE11_RS22020 Protein ID WP_011738542.1
Coordinates 5367554..5367742 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMARE11_RS21990 5362278..5363798 + 1521 WP_020729620.1 carotenoid oxygenase family protein -
MMARE11_RS21995 5363815..5364288 + 474 WP_012396158.1 VOC family protein -
MMARE11_RS22000 5364294..5364728 - 435 WP_038580760.1 hypothetical protein -
MMARE11_RS22005 5364799..5365572 - 774 WP_020729619.1 VOC family protein -
MMARE11_RS22010 5365741..5366991 + 1251 WP_036456440.1 hypothetical protein -
MMARE11_RS22015 5367103..5367549 - 447 WP_020729617.1 SRPBCC family protein Toxin
MMARE11_RS22020 5367554..5367742 - 189 WP_011738542.1 antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15851.39 Da        Isoelectric Point: 8.6574

>T285136 WP_020729617.1 NZ_HG917972:c5367549-5367103 [Mycobacterium marinum E11]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSVVSFDVHLGGPALFGPIGMVVAAALRTDINASLRNFVTVFAPSAAG

Download         Length: 447 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6586.35 Da        Isoelectric Point: 4.7205

>AT285136 WP_011738542.1 NZ_HG917972:c5367742-5367554 [Mycobacterium marinum E11]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5YL42

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LB02

References