Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 4516825..4517327 Replicon chromosome
Accession NZ_HG916826
Organism Pseudomonas pseudoalcaligenes CECT 5344 strain CECT5344

Toxin (Protein)


Gene name yoeB Uniprot ID W6RLX6
Locus tag BN5_RS21290 Protein ID WP_003464804.1
Coordinates 4516825..4517079 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W6R1F7
Locus tag BN5_RS21295 Protein ID WP_003464807.1
Coordinates 4517076..4517327 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN5_RS23000 4511890..4512000 - 111 Protein_4237 TraR/DksA C4-type zinc finger protein -
BN5_RS21270 4512277..4512579 - 303 Protein_4238 RNA polymerase-binding protein DksA -
BN5_RS21275 4512651..4513541 + 891 WP_003464796.1 GTP cyclohydrolase I FolE2 -
BN5_RS21280 4513778..4515697 + 1920 WP_003464798.1 cyclic nucleotide-binding/CBS domain-containing protein -
BN5_RS21285 4515694..4516401 + 708 WP_003464800.1 3'-5' exonuclease -
BN5_RS22245 4516463..4516624 + 162 WP_003464802.1 DUF2986 domain-containing protein -
BN5_RS21290 4516825..4517079 - 255 WP_003464804.1 Txe/YoeB family addiction module toxin Toxin
BN5_RS21295 4517076..4517327 - 252 WP_003464807.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BN5_RS21300 4517482..4518384 - 903 WP_003464809.1 LysR family transcriptional regulator -
BN5_RS21305 4518568..4519956 + 1389 WP_003464812.1 L-serine ammonia-lyase -
BN5_RS21310 4520214..4521881 - 1668 WP_003464814.1 BCCT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4417566..4590578 173012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10268.83 Da        Isoelectric Point: 9.8757

>T285134 WP_003464804.1 NZ_HG916826:c4517079-4516825 [Pseudomonas pseudoalcaligenes CECT 5344]
VNLVFSEQAWADYLYWQGQDKKTLKRINELLKEIKRTPFEGMGKPEPLKHALAGYWSRRINEEHRLVYRLREHEILIAQV
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9255.54 Da        Isoelectric Point: 4.5535

>AT285134 WP_003464807.1 NZ_HG916826:c4517327-4517076 [Pseudomonas pseudoalcaligenes CECT 5344]
MDAITYSTARANLANTMDRVCEDHEPIIITRNGQQAVVMMSLDDYKALEETAYLLRSPKNAQRLLESIAALETGKGVTRE
LDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W6RLX6

Antitoxin

Source ID Structure
AlphaFold DB W6R1F7

References