Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2437274..2437827 Replicon chromosome
Accession NZ_HG916826
Organism Pseudomonas pseudoalcaligenes CECT 5344 strain CECT5344

Toxin (Protein)


Gene name parE Uniprot ID A0A385B7Q1
Locus tag BN5_RS11315 Protein ID WP_003461247.1
Coordinates 2437274..2437567 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W6RG82
Locus tag BN5_RS11320 Protein ID WP_003461245.1
Coordinates 2437555..2437827 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN5_RS11290 2432855..2434201 - 1347 WP_003461262.1 glutamine synthetase family protein -
BN5_RS11295 2434231..2434788 - 558 WP_021489866.1 helix-turn-helix domain-containing protein -
BN5_RS11300 2434805..2436094 - 1290 WP_003461258.1 FAD-binding oxidoreductase -
BN5_RS11305 2436273..2436677 - 405 Protein_2248 DUF262 domain-containing protein -
BN5_RS11310 2436606..2437280 + 675 Protein_2249 site-specific integrase -
BN5_RS11315 2437274..2437567 - 294 WP_003461247.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BN5_RS11320 2437555..2437827 - 273 WP_003461245.1 CopG family ribbon-helix-helix protein Antitoxin
BN5_RS11325 2438016..2439515 + 1500 WP_003461243.1 IS21-like element ISPst3 family transposase -
BN5_RS23285 2439508..2440313 + 806 Protein_2253 IS21-like element helper ATPase IstB -
BN5_RS11335 2440508..2441254 + 747 Protein_2254 AIPR family protein -
BN5_RS23635 2441273..2442115 - 843 WP_003461234.1 hypothetical protein -
BN5_RS23290 2442125..2442760 - 636 WP_052678213.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11183.67 Da        Isoelectric Point: 5.9081

>T285131 WP_003461247.1 NZ_HG916826:c2437567-2437274 [Pseudomonas pseudoalcaligenes CECT 5344]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRVAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10477.71 Da        Isoelectric Point: 6.7193

>AT285131 WP_003461245.1 NZ_HG916826:c2437827-2437555 [Pseudomonas pseudoalcaligenes CECT 5344]
MATSIKIDDKLKGRILQLASQRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTSQETRAWLGSWGTD
TEVELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A385B7Q1

Antitoxin

Source ID Structure
AlphaFold DB W6RG82

References