Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1219466..1220868 Replicon chromosome
Accession NZ_HG916826
Organism Pseudomonas pseudoalcaligenes CECT 5344 strain CECT5344

Toxin (Protein)


Gene name - Uniprot ID W6QUR4
Locus tag BN5_RS05525 Protein ID WP_003462563.1
Coordinates 1219466..1220035 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2W5WET3
Locus tag BN5_RS05530 Protein ID WP_039964860.1
Coordinates 1220041..1220868 (+) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN5_RS05520 1215775..1219263 - 3489 WP_003462567.1 hybrid sensor histidine kinase/response regulator -
BN5_RS05525 1219466..1220035 + 570 WP_003462563.1 GNAT family N-acetyltransferase Toxin
BN5_RS05530 1220041..1220868 + 828 WP_039964860.1 AraC family transcriptional regulator Antitoxin
BN5_RS05535 1221767..1223104 - 1338 WP_003462552.1 peptidase -
BN5_RS05540 1223294..1223866 + 573 WP_003462549.1 LemA family protein -
BN5_RS05545 1223877..1224782 + 906 WP_003462547.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(17-142)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21497.72 Da        Isoelectric Point: 8.9246

>T285130 WP_003462563.1 NZ_HG916826:1219466-1220035 [Pseudomonas pseudoalcaligenes CECT 5344]
MFKPQLVTLQRGALRLEPLSDADIPALVALAEANREELLYMSGTQRLDWYRSALADMREQRALPFVIRLGNEWVGTTRFA
DFMNPLPACEIGWTWLDRNQHGSGLNTSIKYLMLKHAFENWGMVRVQLKTAASNLRSQRAIEKLGAVREGLLRNHRRLAD
GRLDDTVLYSITDLEWPALRGAMEAGFNA

Download         Length: 570 bp

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30840.23 Da        Isoelectric Point: 8.3478

>AT285130 WP_039964860.1 NZ_HG916826:1220041-1220868 [Pseudomonas pseudoalcaligenes CECT 5344]
MHSREQTRFWQASALSGVELLQARYLEQRFAPHVHEGFVFTVIEHGAQRFRHRGCDHLAPQGSMVLINPDEVHTGSKAHE
DGWRYRGFYPDNAQVLGALQELGLAKAGMPSFAFSVLHDPRLHAAFLQLHQLLEGGAEALQQQLAWREAMLLLFQHHAQL
AEPPAPGREPWAVACAKQMLAERLIEPPSLEELAAAVNLSPFHFARVFRRETGLPPHAWLKQRRLEQARALLKTGCTAVA
VAMQLGFADQSHLSRQFKQVYGVSPGEYRSAVARS

Download         Length: 828 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W6QUR4

Antitoxin

Source ID Structure
AlphaFold DB A0A2W5WET3

References