Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1210928..1212135 Replicon chromosome
Accession NZ_HG916826
Organism Pseudomonas pseudoalcaligenes CECT 5344 strain CECT5344

Toxin (Protein)


Gene name - Uniprot ID W6QUQ8
Locus tag BN5_RS05500 Protein ID WP_003462580.1
Coordinates 1211383..1212135 (+) Length 251 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W6QTC2
Locus tag BN5_RS05495 Protein ID WP_003462583.1
Coordinates 1210928..1211299 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN5_RS05475 1206602..1206928 + 327 WP_003246056.1 Grx4 family monothiol glutaredoxin -
BN5_RS05480 1207674..1208012 - 339 WP_003462591.1 YdbL family protein -
BN5_RS05485 1208044..1208235 - 192 WP_003462588.1 YnbE family lipoprotein -
BN5_RS05490 1208240..1210795 - 2556 WP_003462586.1 YdbH domain-containing protein -
BN5_RS05495 1210928..1211299 + 372 WP_003462583.1 XRE family transcriptional regulator Antitoxin
BN5_RS05500 1211383..1212135 + 753 WP_003462580.1 RES family NAD+ phosphorylase Toxin
BN5_RS05505 1212573..1212824 + 252 WP_017675070.1 sel1 repeat family protein -
BN5_RS05510 1213004..1214365 + 1362 WP_162884251.1 DNA recombination protein RmuC -
BN5_RS05515 1214380..1215327 - 948 WP_003462570.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(62-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(72-121)


Sequences

Toxin        


Download         Length: 251 a.a.        Molecular weight: 28505.52 Da        Isoelectric Point: 7.5090

>T285129 WP_003462580.1 NZ_HG916826:1211383-1212135 [Pseudomonas pseudoalcaligenes CECT 5344]
MDIWQLCDGERQVRPLRGKLLRMVESQAQVATLQLVDNLAEQTLLEELLESSKPPLPEAAEPLHYLLKTPFRYPPLRWGS
RFGRVHEPSLFYAAQRLQTAMAEAAYYRFVLWNGMVVPPPSGRILSEHSTFEARYRVEHGIQLQQSPFAQHDALLAHPSD
YSVPQRLGTSMRAAGIQAFEYRSARCPDGGSNVALYVPAAFVEKRPRNLTAWLCETTSEYVAFKHAQTPDQPRLFHWEQF
LVQGQLPHPA

Download         Length: 753 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13661.73 Da        Isoelectric Point: 10.6604

>AT285129 WP_003462583.1 NZ_HG916826:1210928-1211299 [Pseudomonas pseudoalcaligenes CECT 5344]
MSAVTRSQPDADAVLAKALLNTREQLGLTQQELADIVGVHRSAISRWSEQGGLRPQSKTGELALLLIRAYRALFALFGGN
QQDMRHFLRTENRHLAGIPLQQMSQVQGLVRVVEYLDAIRGKV

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W6QUQ8

Antitoxin

Source ID Structure
AlphaFold DB W6QTC2

References