Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 836090..836766 Replicon chromosome
Accession NZ_HG916826
Organism Pseudomonas pseudoalcaligenes CECT 5344 strain CECT5344

Toxin (Protein)


Gene name vapC Uniprot ID W6QYZ7
Locus tag BN5_RS03745 Protein ID WP_004424726.1
Coordinates 836341..836766 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W6QR28
Locus tag BN5_RS03740 Protein ID WP_004424728.1
Coordinates 836090..836341 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN5_RS03725 832596..835253 + 2658 WP_039965052.1 CRISPR-associated helicase/endonuclease Cas3 -
BN5_RS03730 835256..835537 - 282 WP_004424733.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
BN5_RS03735 835534..835824 - 291 WP_004424730.1 hypothetical protein -
BN5_RS03740 836090..836341 + 252 WP_004424728.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BN5_RS03745 836341..836766 + 426 WP_004424726.1 type II toxin-antitoxin system VapC family toxin Toxin
BN5_RS03750 836876..838411 + 1536 WP_004424723.1 type I-E CRISPR-associated protein Cse1/CasA -
BN5_RS03755 838408..838950 + 543 WP_004424722.1 type I-E CRISPR-associated protein Cse2/CasB -
BN5_RS03760 838961..840103 + 1143 WP_004424719.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
BN5_RS03765 840106..840768 + 663 WP_004424717.1 type I-E CRISPR-associated protein Cas5/CasD -
BN5_RS03770 840743..841357 + 615 WP_004424714.1 type I-E CRISPR-associated protein Cas6/Cse3/CasE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-58)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15393.95 Da        Isoelectric Point: 8.0845

>T285128 WP_004424726.1 NZ_HG916826:836341-836766 [Pseudomonas pseudoalcaligenes CECT 5344]
MFVLDTNVVSELRKAKSAKADPRLVAWAQRLLPGQLFISAITVLELETGVLLVERRDPQQGRLLRSWLDSHVLPGFAGRI
LPVDAAVAQRCAQLHVPDPRAERDALIVATALVHGMTVATRNVADFLPTGVALINPWEFAG

Download         Length: 426 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8989.20 Da        Isoelectric Point: 5.6492

>AT285128 WP_004424728.1 NZ_HG916826:836090-836341 [Pseudomonas pseudoalcaligenes CECT 5344]
MQTILTSREFNQDASGAKRAAKHGPVFITDRGKPAHVLLSIEEYQRLTGGPGSIIDLLAMPTVEDIEFEAPRAQGLSRPA
DLS

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W6QYZ7

Antitoxin

Source ID Structure
AlphaFold DB W6QR28

References