Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 835256..835824 Replicon chromosome
Accession NZ_HG916826
Organism Pseudomonas pseudoalcaligenes CECT 5344 strain CECT5344

Toxin (Protein)


Gene name parE Uniprot ID W6QTT6
Locus tag BN5_RS03730 Protein ID WP_004424733.1
Coordinates 835256..835537 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID W6RBZ2
Locus tag BN5_RS03735 Protein ID WP_004424730.1
Coordinates 835534..835824 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN5_RS03725 832596..835253 + 2658 WP_039965052.1 CRISPR-associated helicase/endonuclease Cas3 -
BN5_RS03730 835256..835537 - 282 WP_004424733.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BN5_RS03735 835534..835824 - 291 WP_004424730.1 hypothetical protein Antitoxin
BN5_RS03740 836090..836341 + 252 WP_004424728.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BN5_RS03745 836341..836766 + 426 WP_004424726.1 type II toxin-antitoxin system VapC family toxin -
BN5_RS03750 836876..838411 + 1536 WP_004424723.1 type I-E CRISPR-associated protein Cse1/CasA -
BN5_RS03755 838408..838950 + 543 WP_004424722.1 type I-E CRISPR-associated protein Cse2/CasB -
BN5_RS03760 838961..840103 + 1143 WP_004424719.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
BN5_RS03765 840106..840768 + 663 WP_004424717.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10565.07 Da        Isoelectric Point: 8.6765

>T285127 WP_004424733.1 NZ_HG916826:c835537-835256 [Pseudomonas pseudoalcaligenes CECT 5344]
VKLAWTRLALNDRQAIRSYIAQDNPIATLALDELFTEKASRLADHPGLGRPGRVSGTRELVVHQHDLMIYDLVNDQVRIL
RVLHTARQWPSAD

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10878.08 Da        Isoelectric Point: 4.7266

>AT285127 WP_004424730.1 NZ_HG916826:c835824-835534 [Pseudomonas pseudoalcaligenes CECT 5344]
MSEATFTFRVDDALKSEFAQAAKARDRTGAQLLRDFMRDFVRQQQEAAEHDVWLRRQVQMGLDSANAGELLSSEEVEAEA
AAWRAEMRRKLDSAAS

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W6QTT6

Antitoxin

Source ID Structure
AlphaFold DB W6RBZ2

References