Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 51786..52363 Replicon plasmid LM6179
Accession NZ_HG813250
Organism Listeria monocytogenes 6179

Toxin (Protein)


Gene name mazF Uniprot ID H1G8D6
Locus tag LM6179_RS15455 Protein ID WP_003728465.1
Coordinates 52022..52363 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1G8D5
Locus tag LM6179_RS15450 Protein ID WP_003728464.1
Coordinates 51786..52028 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM6179_RS15425 49312..49800 - 489 WP_031669356.1 hypothetical protein -
LM6179_RS15430 49959..50336 - 378 WP_003769263.1 DUF3850 domain-containing protein -
LM6179_RS15435 50355..51017 - 663 WP_003731676.1 DUF2786 domain-containing protein -
LM6179_RS15440 51017..51343 - 327 WP_031641563.1 hypothetical protein -
LM6179_RS15445 51474..51725 + 252 WP_003728463.1 hypothetical protein -
LM6179_RS15450 51786..52028 + 243 WP_003728464.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LM6179_RS15455 52022..52363 + 342 WP_003728465.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LM6179_RS16060 52389..52532 - 144 WP_157105793.1 hypothetical protein -
LM6179_RS15460 52586..53557 - 972 WP_031641941.1 hypothetical protein -
LM6179_RS15465 53561..53812 - 252 WP_049955716.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..62206 62206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 14629.86 Da        Isoelectric Point: 12.8531

>T285116 WP_003728465.1 NZ_HG813250:52022-52363 [Listeria monocytogenes 6179]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 342 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 10400.12 Da        Isoelectric Point: 12.7030

>AT285116 WP_003728464.1 NZ_HG813250:51786-52028 [Listeria monocytogenes 6179]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H1G8D6

Antitoxin

Source ID Structure
AlphaFold DB H1G8D5

References