285115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1738793..1739302 Replicon chromosome
Accession NZ_HG813242
Organism Staphylococcus epidermidis PM221

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag SEB_RS08290 Protein ID WP_001829980.1
Coordinates 1738793..1739002 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag SEB_RS08295 Protein ID WP_001829893.1
Coordinates 1739009..1739302 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEB_RS08270 1734372..1735727 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SEB_RS08275 1735739..1736812 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
SEB_RS08280 1737203..1738414 + 1212 WP_002486299.1 rod shape-determining protein RodA -
SEB_RS08285 1738513..1738650 - 138 WP_001829949.1 hypothetical protein -
SEB_RS08290 1738793..1739002 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
SEB_RS08295 1739009..1739302 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
SEB_RS08300 1739476..1740960 + 1485 WP_002457116.1 cardiolipin synthase -
SEB_RS08305 1741142..1741795 + 654 WP_001829983.1 HD domain-containing protein -
SEB_RS08310 1741901..1742773 - 873 WP_002458703.1 membrane protein insertase YidC -
SEB_RS08315 1742862..1743500 - 639 WP_002505076.1 thiamine phosphate synthase -
SEB_RS08320 1743506..1744294 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T285115 WP_001829980.1 NZ_HG813242:c1739002-1738793 [Staphylococcus epidermidis PM221]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT285115 WP_001829893.1 NZ_HG813242:c1739302-1739009 [Staphylococcus epidermidis PM221]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References