285114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1727589..1728118 Replicon chromosome
Accession NZ_HG813242
Organism Staphylococcus epidermidis PM221

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag SEB_RS08230 Protein ID WP_001829891.1
Coordinates 1727589..1727951 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag SEB_RS08235 Protein ID WP_001829931.1
Coordinates 1727948..1728118 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEB_RS08210 1724591..1725361 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
SEB_RS08215 1725336..1725815 - 480 WP_001829903.1 anti-sigma B factor RsbW -
SEB_RS08220 1725817..1726143 - 327 WP_001829952.1 anti-sigma factor antagonist -
SEB_RS08225 1726243..1727244 - 1002 WP_038399520.1 PP2C family protein-serine/threonine phosphatase -
SEB_RS08230 1727589..1727951 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SEB_RS08235 1727948..1728118 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SEB_RS08240 1728205..1729353 - 1149 WP_002457107.1 alanine racemase -
SEB_RS08245 1729420..1729773 - 354 WP_002457108.1 holo-ACP synthase -
SEB_RS08250 1729821..1730330 - 510 WP_002457109.1 PH domain-containing protein -
SEB_RS08255 1730317..1731822 - 1506 WP_002457110.1 PH domain-containing protein -
SEB_RS08260 1731815..1732294 - 480 WP_002457111.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T285114 WP_001829891.1 NZ_HG813242:c1727951-1727589 [Staphylococcus epidermidis PM221]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT285114 WP_001829931.1 NZ_HG813242:c1728118-1727948 [Staphylococcus epidermidis PM221]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References