Detailed information of TA system TA028511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 947057..947567
• Replicon: chromosome
• Accession: NC_019684
• Organism: Nostoc sp. PCC 7524 (Nostoc sp. ATCC 29411)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K9QNH7
• Locus tag: NOS7524_RS04005
• Protein ID: WP_015137189.1
• Coordinates: 947289..947567 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: K9QM68
• Locus tag: NOS7524_RS04000
• Protein ID: WP_015137188.1
• Coordinates: 947057..947299 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOS7524_RS03975	942509..944086	+	1578	WP_015137182.1	photosynthetic/respiratory NAD(P)H-quinone oxidoreductase subunit D1	-
NOS7524_RS03980	944362..945081	+	720	WP_015137184.1	Uma2 family endonuclease	-
NOS7524_RS03985	945309..945989	+	681	WP_015137185.1	hypothetical protein	-
NOS7524_RS03990	945996..946190	-	195	WP_015137186.1	DUF433 domain-containing protein	-
NOS7524_RS03995	946193..946855	-	663	WP_015137187.1	Uma2 family endonuclease	-
NOS7524_RS04000	947057..947299	+	243	WP_015137188.1	transcriptional regulator	Antitoxin
NOS7524_RS04005	947289..947567	+	279	WP_015137189.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
NOS7524_RS04010	947658..947858	-	201	WP_015137190.1	hypothetical protein	-
NOS7524_RS04015	948039..948272	+	234	WP_015137191.1	DUF433 domain-containing protein	-
NOS7524_RS28170	948299..948466	-	168	Protein_807	type II toxin-antitoxin system HicB family antitoxin	-
NOS7524_RS04020	948629..949051	-	423	WP_015137192.1	hypothetical protein	-
NOS7524_RS04025	949443..949715	-	273	WP_015137193.1	DUF1049 domain-containing protein	-
NOS7524_RS04030	949796..951220	-	1425	WP_041555543.1	phosphoglucomutase/phosphomannomutase family protein	-
NOS7524_RS04035	951327..952199	+	873	WP_015137195.1	PD-(D/E)XK nuclease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10812.68 Da
• Isoelectric Point: 10.6254

>T28511 WP_015137189.1 NC_019684:947289-947567 [Nostoc sp. PCC 7524]
MQIKWLRRALRNLKQAHDYILKDNPQAAREVILRIQSAANQLESYPLMGRLGRVEGTRELVIANTPYILIYRVKLESVEI
LRVLHTSKRYPD

Nucleotide

• Length: 279 bp

>T28511 NC_019684:947289-947567 [Nostoc sp. PCC 7524]
ATGCAGATTAAATGGCTACGTCGCGCGCTGCGTAATTTAAAACAAGCACATGATTACATCCTCAAAGACAATCCACAAGC
AGCGCGAGAAGTCATATTGAGGATTCAAAGTGCTGCAAACCAATTGGAGAGTTATCCCTTGATGGGACGACTAGGACGTG
TGGAAGGTACAAGAGAATTAGTAATTGCTAATACGCCATACATTCTGATTTACCGAGTCAAACTAGAGTCTGTGGAAATT
CTTCGCGTTCTCCACACTTCCAAACGCTATCCAGATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9035.11 Da
• Isoelectric Point: 4.1953

>AT28511 WP_015137188.1 NC_019684:947057-947299 [Nostoc sp. PCC 7524]
MSKENITFRIESDKKLALEAIAKGINRDRSYVLNEAIDAYLEMHQWQIEEIHKGIAEADAGDFASDEEVMATFAMLTNAD

Nucleotide

• Length: 243 bp

>AT28511 NC_019684:947057-947299 [Nostoc sp. PCC 7524]
ATGAGTAAAGAAAATATTACATTTCGGATAGAGAGTGACAAAAAGCTGGCACTGGAAGCAATTGCCAAAGGTATAAACCG
CGATCGCTCTTATGTACTCAATGAAGCTATAGATGCTTATCTAGAGATGCACCAATGGCAAATAGAAGAAATTCACAAGG
GAATTGCTGAAGCTGATGCAGGAGACTTTGCCAGCGATGAGGAAGTAATGGCAACTTTTGCAATGCTTACCAATGCAGAT
TAA

Structures

Toxin

• AlphaFold DB: K9QNH7

Antitoxin

• AlphaFold DB: K9QM68