Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3165529..3166077 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag MT49_RS15080 Protein ID WP_003414602.1
Coordinates 3165814..3166077 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag MT49_RS15075 Protein ID WP_003414599.1
Coordinates 3165529..3165810 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS15050 3161153..3162010 - 858 WP_003899513.1 type I methionyl aminopeptidase -
MT49_RS15055 3162052..3162636 - 585 WP_003414585.1 DUF1707 domain-containing protein -
MT49_RS15060 3162739..3162987 + 249 WP_003913411.1 antitoxin VapB23 -
MT49_RS15065 3162984..3163364 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
MT49_RS15070 3163446..3165257 - 1812 WP_003414596.1 penicillin-binding protein -
MT49_RS15075 3165529..3165810 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
MT49_RS15080 3165814..3166077 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MT49_RS15085 3166450..3167304 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MT49_RS15090 3167360..3168523 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MT49_RS15095 3168540..3169754 - 1215 WP_003414610.1 zinc metalloprotease Rip -
MT49_RS15100 3169762..3171003 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T285106 WP_003414602.1 NZ_HG813240:3165814-3166077 [Mycobacterium tuberculosis 49-02]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT285106 WP_003414599.1 NZ_HG813240:3165529-3165810 [Mycobacterium tuberculosis 49-02]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References