Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3104414..3104984 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag MT49_RS14750 Protein ID WP_003414166.1
Coordinates 3104414..3104770 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag MT49_RS14755 Protein ID WP_003901465.1
Coordinates 3104754..3104984 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS14730 3099866..3101554 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
MT49_RS14735 3101558..3101884 - 327 WP_003414157.1 hypothetical protein -
MT49_RS14740 3102057..3102644 + 588 WP_003914429.1 DUF3558 family protein -
MT49_RS14745 3102663..3104312 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
MT49_RS14750 3104414..3104770 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
MT49_RS14755 3104754..3104984 - 231 WP_003901465.1 antitoxin MazE Antitoxin
MT49_RS14760 3105027..3106070 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
MT49_RS22240 3106261..3106536 + 276 WP_003911993.1 DUF1778 domain-containing protein -
MT49_RS22540 3106712..3106966 - 255 WP_003917684.1 hypothetical protein -
MT49_RS14775 3107114..3107518 + 405 WP_003414181.1 hypothetical protein -
MT49_RS14780 3107515..3107706 + 192 WP_003414184.1 hypothetical protein -
MT49_RS14785 3107770..3109059 + 1290 Protein_2891 transposase family protein -
MT49_RS14790 3109293..3109550 + 258 WP_003899489.1 hypothetical protein -
MT49_RS14795 3109655..3109966 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T285103 WP_003414166.1 NZ_HG813240:c3104770-3104414 [Mycobacterium tuberculosis 49-02]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT285103 WP_003901465.1 NZ_HG813240:c3104984-3104754 [Mycobacterium tuberculosis 49-02]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References