Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2803520..2804172 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag MT49_RS13170 Protein ID WP_003905869.1
Coordinates 2803747..2804172 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MT49_RS13165 Protein ID WP_003412749.1
Coordinates 2803520..2803741 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS13150 2801760..2801966 - 207 WP_003899347.1 hypothetical protein -
MT49_RS13155 2802102..2802725 + 624 WP_003900858.1 TIGR00725 family protein -
MT49_RS13160 2802715..2803467 + 753 WP_003901416.1 hypothetical protein -
MT49_RS13165 2803520..2803741 + 222 WP_003412749.1 antitoxin Antitoxin
MT49_RS13170 2803747..2804172 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
MT49_RS13175 2804195..2805376 - 1182 WP_003905870.1 2-oxo acid dehydrogenase subunit E2 -
MT49_RS13180 2805373..2806419 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MT49_RS13185 2806430..2807533 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MT49_RS13190 2807792..2808613 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MT49_RS13195 2808610..2809167 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T285094 WP_003905869.1 NZ_HG813240:2803747-2804172 [Mycobacterium tuberculosis 49-02]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT285094 WP_003412749.1 NZ_HG813240:2803520-2803741 [Mycobacterium tuberculosis 49-02]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References