Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 2361315..2362010 | Replicon | chromosome |
Accession | NZ_HG813240 | ||
Organism | Mycobacterium tuberculosis 49-02 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | MT49_RS11030 | Protein ID | WP_003905754.1 |
Coordinates | 2361315..2361749 (-) | Length | 145 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TMN0 |
Locus tag | MT49_RS11035 | Protein ID | WP_003410814.1 |
Coordinates | 2361756..2362010 (-) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MT49_RS11020 | 2357469..2360510 | + | 3042 | WP_003899171.1 | DEAD/DEAH box helicase | - |
MT49_RS11025 | 2360503..2361336 | + | 834 | WP_003899172.1 | SWIM zinc finger family protein | - |
MT49_RS11030 | 2361315..2361749 | - | 435 | WP_003905754.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MT49_RS11035 | 2361756..2362010 | - | 255 | WP_003410814.1 | antitoxin | Antitoxin |
MT49_RS11040 | 2362026..2362283 | - | 258 | WP_003410816.1 | hypothetical protein | - |
MT49_RS11050 | 2362817..2364078 | + | 1262 | WP_087902221.1 | IS3-like element IS987 family transposase | - |
MT49_RS11065 | 2365946..2366242 | + | 297 | WP_003410820.1 | PE family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 145 a.a. Molecular weight: 15632.05 Da Isoelectric Point: 7.4681
>T285092 WP_003905754.1 NZ_HG813240:c2361749-2361315 [Mycobacterium tuberculosis 49-02]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL
Download Length: 435 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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