Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2361315..2362010 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MT49_RS11030 Protein ID WP_003905754.1
Coordinates 2361315..2361749 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag MT49_RS11035 Protein ID WP_003410814.1
Coordinates 2361756..2362010 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS11020 2357469..2360510 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
MT49_RS11025 2360503..2361336 + 834 WP_003899172.1 SWIM zinc finger family protein -
MT49_RS11030 2361315..2361749 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
MT49_RS11035 2361756..2362010 - 255 WP_003410814.1 antitoxin Antitoxin
MT49_RS11040 2362026..2362283 - 258 WP_003410816.1 hypothetical protein -
MT49_RS11050 2362817..2364078 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
MT49_RS11065 2365946..2366242 + 297 WP_003410820.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T285092 WP_003905754.1 NZ_HG813240:c2361749-2361315 [Mycobacterium tuberculosis 49-02]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT285092 WP_003410814.1 NZ_HG813240:c2362010-2361756 [Mycobacterium tuberculosis 49-02]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References