Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2248840..2249466 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag MT49_RS10520 Protein ID WP_003410075.1
Coordinates 2249068..2249466 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag MT49_RS10515 Protein ID WP_003911750.1
Coordinates 2248840..2249067 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS10505 2246879..2247223 - 345 WP_003410065.1 ferredoxin family protein -
MT49_RS10510 2247412..2248581 - 1170 WP_003899126.1 ATP-binding protein -
MT49_RS10515 2248840..2249067 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MT49_RS10520 2249068..2249466 + 399 WP_003410075.1 PIN domain nuclease Toxin
MT49_RS10525 2249649..2250080 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
MT49_RS10530 2250181..2250615 + 435 WP_003914358.1 DUF1398 domain-containing protein -
MT49_RS21355 2251052..2251231 - 180 Protein_2064 hypothetical protein -
MT49_RS10535 2251292..2251939 + 648 WP_071854215.1 transposase -
MT49_RS10540 2251893..2252483 + 591 WP_003899131.1 IS110 family transposase -
MT49_RS10545 2252611..2253867 - 1257 WP_003902247.1 HNH endonuclease -
MT49_RS10550 2254221..2254421 + 201 Protein_2068 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T285089 WP_003410075.1 NZ_HG813240:2249068-2249466 [Mycobacterium tuberculosis 49-02]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT285089 WP_003911750.1 NZ_HG813240:2248840-2249067 [Mycobacterium tuberculosis 49-02]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References