Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2216209..2216897 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MT49_RS10350 Protein ID WP_003409958.1
Coordinates 2216209..2216628 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MT49_RS10355 Protein ID WP_003409968.1
Coordinates 2216637..2216897 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS10330 2211704..2212552 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
MT49_RS10335 2212515..2213960 - 1446 WP_003899115.1 APC family permease -
MT49_RS10340 2214139..2214825 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
MT49_RS10345 2215016..2215984 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MT49_RS10350 2216209..2216628 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MT49_RS10355 2216637..2216897 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MT49_RS10360 2217040..2218716 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
MT49_RS10365 2218704..2219357 - 654 WP_003409976.1 cutinase Cfp21 -
MT49_RS10370 2219472..2219702 + 231 WP_003409980.1 DUF167 domain-containing protein -
MT49_RS10375 2219787..2220698 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MT49_RS10380 2220807..2221406 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T285086 WP_003409958.1 NZ_HG813240:c2216628-2216209 [Mycobacterium tuberculosis 49-02]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT285086 WP_003409968.1 NZ_HG813240:c2216897-2216637 [Mycobacterium tuberculosis 49-02]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References