Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2180949..2181652 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag MT49_RS10100 Protein ID WP_003409778.1
Coordinates 2180949..2181278 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag MT49_RS21325 Protein ID WP_003409780.1
Coordinates 2181275..2181652 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS10080 2177332..2178402 + 1071 WP_003902252.1 epoxide hydrolase EphB -
MT49_RS10085 2178399..2178914 + 516 WP_003409718.1 flavin reductase family protein -
MT49_RS10090 2178911..2179972 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MT49_RS10095 2179969..2180739 + 771 WP_003409775.1 SDR family oxidoreductase -
MT49_RS10100 2180949..2181278 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MT49_RS21325 2181275..2181652 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
MT49_RS10110 2181649..2182239 - 591 WP_003409784.1 SEC-C domain-containing protein -
MT49_RS10115 2182294..2183658 + 1365 WP_003903691.1 HNH endonuclease -
MT49_RS10120 2183813..2184265 - 453 WP_003899095.1 lipoprotein -
MT49_RS10125 2184329..2184730 + 402 WP_003409869.1 hypothetical protein -
MT49_RS10130 2184723..2184905 - 183 WP_003409870.1 hypothetical protein -
MT49_RS10135 2185019..2185369 - 351 WP_003409871.1 hypothetical protein -
MT49_RS10140 2185380..2186282 - 903 WP_003899097.1 hypothetical protein -
MT49_RS10145 2186303..2186494 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T285083 WP_003409778.1 NZ_HG813240:c2181278-2180949 [Mycobacterium tuberculosis 49-02]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT285083 WP_003409780.1 NZ_HG813240:c2181652-2181275 [Mycobacterium tuberculosis 49-02]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References