Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1961903..1962363 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag MT49_RS09130 Protein ID WP_003898996.1
Coordinates 1962115..1962363 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag MT49_RS09125 Protein ID WP_003408528.1
Coordinates 1961903..1962115 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS09110 1958381..1959568 - 1188 WP_003898992.1 nitrate transporter NarK -
MT49_RS09115 1959855..1960139 + 285 WP_003408522.1 DUF1876 domain-containing protein -
MT49_RS09120 1960153..1961835 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
MT49_RS09125 1961903..1962115 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MT49_RS09130 1962115..1962363 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
MT49_RS09135 1962371..1963108 + 738 WP_003898997.1 hypothetical protein -
MT49_RS09140 1963202..1964902 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
MT49_RS09145 1965187..1965588 - 402 WP_003408538.1 hypothetical protein -
MT49_RS09150 1965578..1966189 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T285082 WP_003898996.1 NZ_HG813240:1962115-1962363 [Mycobacterium tuberculosis 49-02]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT285082 WP_003408528.1 NZ_HG813240:1961903-1962115 [Mycobacterium tuberculosis 49-02]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References