Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1575575..1576230 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag MT49_RS07415 Protein ID WP_003898861.1
Coordinates 1575575..1575976 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag MT49_RS07420 Protein ID WP_003407272.1
Coordinates 1575973..1576230 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS07400 1571047..1572432 - 1386 WP_003407260.1 cytochrome P450 -
MT49_RS07405 1572510..1573544 + 1035 WP_003407264.1 AraC family transcriptional regulator -
MT49_RS07410 1573590..1575320 - 1731 WP_009940170.1 PE family protein -
MT49_RS07415 1575575..1575976 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
MT49_RS07420 1575973..1576230 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
MT49_RS07425 1576313..1577272 - 960 WP_003407276.1 alpha/beta hydrolase -
MT49_RS07430 1577297..1578259 - 963 WP_003905554.1 alpha/beta hydrolase -
MT49_RS07435 1578258..1578995 + 738 WP_031647000.1 lysoplasmalogenase -
MT49_RS07440 1579076..1581043 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T285078 WP_003898861.1 NZ_HG813240:c1575976-1575575 [Mycobacterium tuberculosis 49-02]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT285078 WP_003407272.1 NZ_HG813240:c1576230-1575973 [Mycobacterium tuberculosis 49-02]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References