Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 1575575..1576230 | Replicon | chromosome |
Accession | NZ_HG813240 | ||
Organism | Mycobacterium tuberculosis 49-02 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WFA6 |
Locus tag | MT49_RS07415 | Protein ID | WP_003898861.1 |
Coordinates | 1575575..1575976 (-) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TIK2 |
Locus tag | MT49_RS07420 | Protein ID | WP_003407272.1 |
Coordinates | 1575973..1576230 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MT49_RS07400 | 1571047..1572432 | - | 1386 | WP_003407260.1 | cytochrome P450 | - |
MT49_RS07405 | 1572510..1573544 | + | 1035 | WP_003407264.1 | AraC family transcriptional regulator | - |
MT49_RS07410 | 1573590..1575320 | - | 1731 | WP_009940170.1 | PE family protein | - |
MT49_RS07415 | 1575575..1575976 | - | 402 | WP_003898861.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MT49_RS07420 | 1575973..1576230 | - | 258 | WP_003407272.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
MT49_RS07425 | 1576313..1577272 | - | 960 | WP_003407276.1 | alpha/beta hydrolase | - |
MT49_RS07430 | 1577297..1578259 | - | 963 | WP_003905554.1 | alpha/beta hydrolase | - |
MT49_RS07435 | 1578258..1578995 | + | 738 | WP_031647000.1 | lysoplasmalogenase | - |
MT49_RS07440 | 1579076..1581043 | + | 1968 | WP_003407285.1 | primosomal protein N' | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14952.43 Da Isoelectric Point: 11.4656
>T285078 WP_003898861.1 NZ_HG813240:c1575976-1575575 [Mycobacterium tuberculosis 49-02]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA
Download Length: 402 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045ISB0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TIK2 |