Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1539852..1540902 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag MT49_RS07245 Protein ID WP_003407164.1
Coordinates 1539852..1540673 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag MT49_RS07250 Protein ID WP_003407167.1
Coordinates 1540666..1540902 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS07225 1535410..1536072 - 663 WP_003407152.1 membrane protein -
MT49_RS07230 1536069..1536854 - 786 WP_003407157.1 membrane protein -
MT49_RS07235 1537145..1539106 - 1962 WP_003407159.1 sigma-F factor regulator -
MT49_RS07240 1539245..1539631 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
MT49_RS07245 1539852..1540673 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
MT49_RS07250 1540666..1540902 + 237 WP_003407167.1 hypothetical protein Antitoxin
MT49_RS07255 1540974..1542179 - 1206 WP_003918234.1 serine hydrolase -
MT49_RS07260 1542482..1543267 + 786 WP_003902048.1 lipoprotein LprF -
MT49_RS07265 1543463..1544077 + 615 Protein_1417 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T285077 WP_003407164.1 NZ_HG813240:1539852-1540673 [Mycobacterium tuberculosis 49-02]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT285077 WP_003407167.1 NZ_HG813240:1540666-1540902 [Mycobacterium tuberculosis 49-02]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References