Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1388562..1389121 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag MT49_RS06595 Protein ID WP_003898789.1
Coordinates 1388562..1388855 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag MT49_RS06600 Protein ID WP_003406322.1
Coordinates 1388852..1389121 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS06570 1384260..1384520 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
MT49_RS06575 1384517..1384948 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
MT49_RS06580 1384971..1386554 - 1584 WP_009940130.1 PE family protein -
MT49_RS06585 1386734..1387594 + 861 WP_003900301.1 hypothetical protein -
MT49_RS06590 1387675..1388505 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
MT49_RS06595 1388562..1388855 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
MT49_RS06600 1388852..1389121 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MT49_RS06605 1389234..1392929 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
MT49_RS06610 1393071..1393859 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T285076 WP_003898789.1 NZ_HG813240:c1388855-1388562 [Mycobacterium tuberculosis 49-02]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT285076 WP_003406322.1 NZ_HG813240:c1389121-1388852 [Mycobacterium tuberculosis 49-02]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References