Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1384260..1384948 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag MT49_RS06575 Protein ID WP_003406304.1
Coordinates 1384517..1384948 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag MT49_RS06570 Protein ID WP_003406302.1
Coordinates 1384260..1384520 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS06550 1379837..1380661 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
MT49_RS06555 1380666..1381847 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
MT49_RS06560 1381924..1383024 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
MT49_RS06565 1383195..1384184 + 990 WP_003406301.1 malate dehydrogenase -
MT49_RS06570 1384260..1384520 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
MT49_RS06575 1384517..1384948 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
MT49_RS06580 1384971..1386554 - 1584 WP_009940130.1 PE family protein -
MT49_RS06585 1386734..1387594 + 861 WP_003900301.1 hypothetical protein -
MT49_RS06590 1387675..1388505 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
MT49_RS06595 1388562..1388855 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
MT49_RS06600 1388852..1389121 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T285075 WP_003406304.1 NZ_HG813240:1384517-1384948 [Mycobacterium tuberculosis 49-02]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT285075 WP_003406302.1 NZ_HG813240:1384260-1384520 [Mycobacterium tuberculosis 49-02]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References