Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1013129..1013748 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MT49_RS04780 Protein ID WP_003404726.1
Coordinates 1013314..1013748 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag MT49_RS04775 Protein ID WP_003898641.1
Coordinates 1013129..1013308 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS04765 1008602..1010182 + 1581 WP_003910977.1 serine hydrolase -
MT49_RS04770 1010179..1012572 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
MT49_RS22435 1012845..1013003 + 159 WP_003404720.1 hypothetical protein -
MT49_RS04775 1013129..1013308 + 180 WP_003898641.1 antitoxin Antitoxin
MT49_RS04780 1013314..1013748 + 435 WP_003404726.1 SRPBCC family protein Toxin
MT49_RS04785 1013846..1014619 + 774 WP_003404735.1 VOC family protein -
MT49_RS04790 1014684..1015133 + 450 WP_003404738.1 hypothetical protein -
MT49_RS04795 1015268..1015498 - 231 WP_003898642.1 hypothetical protein -
MT49_RS04800 1015665..1017173 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
MT49_RS04805 1017175..1018413 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T285071 WP_003404726.1 NZ_HG813240:1013314-1013748 [Mycobacterium tuberculosis 49-02]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT285071 WP_003898641.1 NZ_HG813240:1013129-1013308 [Mycobacterium tuberculosis 49-02]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References