Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4184610..4185279 Replicon chromosome
Accession NZ_HG738868
Organism Serratia marcescens SMB2099

Toxin (Protein)


Gene name cptA Uniprot ID A0A2V4FX75
Locus tag SMB2099_RS19790 Protein ID WP_033649453.1
Coordinates 4184610..4185032 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag SMB2099_RS19795 Protein ID WP_004931679.1
Coordinates 4185013..4185279 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB2099_RS19770 4180499..4181017 + 519 WP_033635825.1 flavodoxin FldB -
SMB2099_RS19775 4181055..4182419 - 1365 WP_041036554.1 cell envelope integrity protein CreD -
SMB2099_RS19780 4182500..4183918 - 1419 WP_079656783.1 two-component system sensor histidine kinase CreC -
SMB2099_RS19785 4183915..4184610 - 696 WP_049232287.1 two-component system response regulator CreB -
SMB2099_RS19790 4184610..4185032 - 423 WP_033649453.1 protein YgfX Toxin
SMB2099_RS19795 4185013..4185279 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
SMB2099_RS19800 4185600..4186592 + 993 WP_079656784.1 tRNA-modifying protein YgfZ -
SMB2099_RS19805 4186631..4187128 - 498 WP_033649451.1 DUF2165 domain-containing protein -
SMB2099_RS19810 4187279..4187953 - 675 WP_079656785.1 hemolysin III family protein -
SMB2099_RS19815 4188137..4188745 + 609 WP_025304127.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16471.59 Da        Isoelectric Point: 10.8114

>T285051 WP_033649453.1 NZ_HG738868:c4185032-4184610 [Serratia marcescens SMB2099]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Download         Length: 423 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT285051 WP_004931679.1 NZ_HG738868:c4185279-4185013 [Serratia marcescens SMB2099]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FX75

Antitoxin

Source ID Structure

References