Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3810993..3811649 Replicon chromosome
Accession NZ_HG738868
Organism Serratia marcescens SMB2099

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4G0W2
Locus tag SMB2099_RS18015 Protein ID WP_041036282.1
Coordinates 3810993..3811382 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag SMB2099_RS18020 Protein ID WP_004941563.1
Coordinates 3811386..3811649 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB2099_RS18000 3807460..3808890 + 1431 WP_033648838.1 MFS transporter -
SMB2099_RS18005 3808887..3810269 + 1383 WP_033635541.1 two-component system sensor histidine kinase BaeS -
SMB2099_RS18010 3810269..3810985 + 717 WP_033635542.1 two-component system response regulator BaeR -
SMB2099_RS18015 3810993..3811382 - 390 WP_041036282.1 type II toxin-antitoxin system VapC family toxin Toxin
SMB2099_RS18020 3811386..3811649 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMB2099_RS18025 3811989..3812327 + 339 WP_033635544.1 YegP family protein -
SMB2099_RS18030 3812508..3813860 + 1353 WP_033635545.1 tRNA 5-hydroxyuridine modification protein YegQ -
SMB2099_RS18040 3814326..3815231 + 906 WP_060428951.1 lipid kinase YegS -
SMB2099_RS18045 3815521..3816570 + 1050 WP_033635553.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14309.56 Da        Isoelectric Point: 7.8786

>T285049 WP_041036282.1 NZ_HG738868:c3811382-3810993 [Serratia marcescens SMB2099]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT285049 WP_004941563.1 NZ_HG738868:c3811649-3811386 [Serratia marcescens SMB2099]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4G0W2

Antitoxin

Source ID Structure

References