Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1628660..1629213 Replicon chromosome
Accession NZ_HG738868
Organism Serratia marcescens SMB2099

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2V4FZ31
Locus tag SMB2099_RS07810 Protein ID WP_019454426.1
Coordinates 1628899..1629213 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag SMB2099_RS07805 Protein ID WP_039566839.1
Coordinates 1628660..1628896 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB2099_RS07790 1625127..1626662 + 1536 WP_033646792.1 glutathione ABC transporter substrate-binding protein GsiB -
SMB2099_RS07795 1626715..1627635 + 921 WP_049213005.1 glutathione ABC transporter permease GsiC -
SMB2099_RS07800 1627645..1628553 + 909 WP_049233469.1 glutathione ABC transporter permease GsiD -
SMB2099_RS07805 1628660..1628896 + 237 WP_039566839.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SMB2099_RS07810 1628899..1629213 + 315 WP_019454426.1 CcdB family protein Toxin
SMB2099_RS07815 1629253..1630095 - 843 WP_049213004.1 S-formylglutathione hydrolase -
SMB2099_RS07820 1630110..1631234 - 1125 WP_033637718.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
SMB2099_RS07825 1631265..1632185 - 921 WP_049213003.1 LysR family transcriptional regulator -
SMB2099_RS07830 1632291..1633448 + 1158 WP_049213010.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - yagZ/ecpA / yagW/ecpD / galU / galF / wza / manB / galE / gnd 1515045..1744650 229605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11745.68 Da        Isoelectric Point: 5.0488

>T285043 WP_019454426.1 NZ_HG738868:1628899-1629213 [Serratia marcescens SMB2099]
MQFTVYANRGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRTRIKAAIDFLLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9068.10 Da        Isoelectric Point: 5.7070

>AT285043 WP_039566839.1 NZ_HG738868:1628660-1628896 [Serratia marcescens SMB2099]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLTAALDAELRQHERIKWQEENREALEALNRFNDEHGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FZ31

Antitoxin

Source ID Structure

References