Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 63238..63839 Replicon chromosome
Accession NZ_HG738868
Organism Serratia marcescens SMB2099

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SMB2099_RS00305 Protein ID WP_060439330.1
Coordinates 63238..63618 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag SMB2099_RS00310 Protein ID WP_004933932.1
Coordinates 63618..63839 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB2099_RS00280 58491..59771 + 1281 WP_079656084.1 DUF3748 domain-containing protein -
SMB2099_RS00285 59802..60149 - 348 WP_033636538.1 YceK/YidQ family lipoprotein -
SMB2099_RS00290 60460..60873 + 414 WP_047569943.1 heat shock chaperone IbpA -
SMB2099_RS00295 60974..61402 + 429 WP_079656085.1 heat shock chaperone IbpB -
SMB2099_RS00300 61569..63227 + 1659 WP_033649549.1 putative transporter -
SMB2099_RS00305 63238..63618 - 381 WP_060439330.1 type II toxin-antitoxin system VapC family toxin Toxin
SMB2099_RS00310 63618..63839 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
SMB2099_RS00315 63914..65164 - 1251 WP_004933935.1 valine--pyruvate transaminase -
SMB2099_RS00320 65300..67363 - 2064 WP_079656086.1 alpha-amylase -
SMB2099_RS24460 67560..67712 + 153 WP_019455508.1 hypothetical protein -
SMB2099_RS00325 67714..68691 - 978 WP_033636542.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14167.50 Da        Isoelectric Point: 7.3170

>T285039 WP_060439330.1 NZ_HG738868:c63618-63238 [Serratia marcescens SMB2099]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLIPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT285039 WP_004933932.1 NZ_HG738868:c63839-63618 [Serratia marcescens SMB2099]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References