Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4449288..4449889 Replicon chromosome
Accession NZ_HG326223
Organism Serratia marcescens subsp. marcescens Db11

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag SMDB11_RS20695 Protein ID WP_025304766.1
Coordinates 4449288..4449668 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag SMDB11_RS20700 Protein ID WP_025304767.1
Coordinates 4449668..4449889 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMDB11_RS20670 4444535..4445815 + 1281 WP_025304764.1 DUF3748 domain-containing protein -
SMDB11_RS20675 4445846..4446193 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
SMDB11_RS20680 4446503..4446916 + 414 WP_004933919.1 heat shock chaperone IbpA -
SMDB11_RS20685 4447023..4447451 + 429 WP_004933922.1 heat shock chaperone IbpB -
SMDB11_RS20690 4447619..4449277 + 1659 WP_025304765.1 putative transporter -
SMDB11_RS20695 4449288..4449668 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
SMDB11_RS20700 4449668..4449889 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
SMDB11_RS20705 4449964..4451214 - 1251 WP_025304768.1 valine--pyruvate transaminase -
SMDB11_RS20710 4451350..4453413 - 2064 WP_025304769.1 alpha-amylase -
SMDB11_RS24830 4453610..4453762 + 153 WP_162837931.1 hypothetical protein -
SMDB11_RS20715 4453764..4454741 - 978 WP_025304770.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T285001 WP_025304766.1 NZ_HG326223:c4449668-4449288 [Serratia marcescens subsp. marcescens Db11]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT285001 WP_025304767.1 NZ_HG326223:c4449889-4449668 [Serratia marcescens subsp. marcescens Db11]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References