Detailed information of TA system TA028500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /PIN(toxin)
• Location: 2021445..2021875
• Replicon: chromosome
• Accession: NC_019680
• Organism: Synechococcus sp. PCC 6312

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SYN6312_RS09850
• Protein ID: WP_051020993.1
• Coordinates: 2021445..2021642 (-)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: K9RUP8
• Locus tag: SYN6312_RS09855
• Protein ID: WP_015124731.1
• Coordinates: 2021642..2021875 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYN6312_RS09830	2017420..2019519	-	2100	WP_015124728.1	DEAD/DEAH box helicase	-
SYN6312_RS09835	2019663..2020118	-	456	WP_015124729.1	type II toxin-antitoxin system death-on-curing family toxin	-
SYN6312_RS09840	2020122..2021135	-	1014	WP_015124730.1	hypothetical protein	-
SYN6312_RS09845	2021141..2021443	-	303	Protein_1972	hypothetical protein	-
SYN6312_RS09850	2021445..2021642	-	198	WP_051020993.1	hypothetical protein	Toxin
SYN6312_RS09855	2021642..2021875	-	234	WP_015124731.1	DUF2281 domain-containing protein	Antitoxin
SYN6312_RS09860	2021927..2022523	-	597	WP_015124732.1	Uma2 family endonuclease	-
SYN6312_RS09865	2022563..2022946	-	384	WP_015124733.1	DUF5615 family PIN-like protein	-
SYN6312_RS09870	2022943..2023176	-	234	WP_041430810.1	DUF433 domain-containing protein	-
SYN6312_RS09875	2023205..2023495	-	291	Protein_1978	hypothetical protein	-
SYN6312_RS09880	2023497..2023913	-	417	WP_015124735.1	PIN domain-containing protein	-
SYN6312_RS09885	2023910..2024140	-	231	WP_015124736.1	hypothetical protein	-
SYN6312_RS09890	2024156..2024389	-	234	WP_015124737.1	YgiT-type zinc finger protein	-
SYN6312_RS09895	2024379..2024711	-	333	WP_015124738.1	DUF4258 domain-containing protein	-
SYN6312_RS09900	2024834..2025085	-	252	WP_015124739.1	UPF0175 family protein	-
SYN6312_RS09905	2025115..2025501	-	387	WP_015124740.1	HEPN domain-containing protein	-
SYN6312_RS09910	2025498..2025818	-	321	WP_015124741.1	nucleotidyltransferase domain-containing protein	-
SYN6312_RS09915	2026073..2026321	-	249	WP_015124742.1	DUF4926 domain-containing protein	-
SYN6312_RS09920	2026324..2026653	-	330	Protein_1987	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Domain of unknown function DUF2281 (6-55)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7277.55 Da
• Isoelectric Point: 4.0339

>T28500 WP_051020993.1 NC_019680:c2021642-2021445 [Synechococcus sp. PCC 6312]
MRTLIDTNIILDFLLERPLFFEDAVQIFCAVAQGLDAIVTRDTQGFSSSPILVLSVQELLIQIKP

Nucleotide

• Length: 198 bp

>T28500 NC_019680:c2021642-2021445 [Synechococcus sp. PCC 6312]
ATGAGAACATTAATAGATACCAACATCATTCTGGATTTTCTGCTGGAGCGACCCTTATTTTTTGAGGATGCGGTTCAGAT
TTTTTGTGCCGTGGCCCAAGGCCTGGATGCAATTGTCACCCGCGATACGCAAGGCTTTTCGAGTTCGCCTATTCTAGTAT
TATCAGTTCAGGAACTACTAATTCAGATCAAGCCCTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8963.34 Da
• Isoelectric Point: 7.2036

>AT28500 WP_015124731.1 NC_019680:c2021875-2021642 [Synechococcus sp. PCC 6312]
MTTAEKLHQLIATLSEKQIREVLRFAELIQQKQLTTTQSEQSRAIQTMRGLLKTDHAPPTDEEVIALLEQRRMDKYL

Nucleotide

• Length: 234 bp

>AT28500 NC_019680:c2021875-2021642 [Synechococcus sp. PCC 6312]
ATGACTACCGCTGAAAAACTCCATCAACTCATCGCAACCCTTTCAGAAAAGCAGATCCGTGAAGTCCTGCGCTTTGCCGA
ACTGATCCAGCAAAAACAACTCACCACAACCCAATCCGAGCAGTCTAGAGCGATTCAAACAATGCGGGGCCTGCTCAAAA
CGGATCACGCACCACCCACAGATGAAGAGGTAATTGCCCTGTTAGAACAACGCCGCATGGATAAATATTTGTAA

Structures

Antitoxin

• AlphaFold DB: K9RUP8