Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3118530..3119186 Replicon chromosome
Accession NZ_HG326223
Organism Serratia marcescens subsp. marcescens Db11

Toxin (Protein)


Gene name vapC Uniprot ID A0A656VD00
Locus tag SMDB11_RS14600 Protein ID WP_025303864.1
Coordinates 3118530..3118919 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag SMDB11_RS14605 Protein ID WP_004941563.1
Coordinates 3118923..3119186 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMDB11_RS14585 3114997..3116427 + 1431 WP_025303862.1 MFS transporter -
SMDB11_RS14590 3116424..3117806 + 1383 WP_025303863.1 two-component system sensor histidine kinase BaeS -
SMDB11_RS14595 3117806..3118522 + 717 WP_004941568.1 two-component system response regulator BaeR -
SMDB11_RS14600 3118530..3118919 - 390 WP_025303864.1 type II toxin-antitoxin system VapC family toxin Toxin
SMDB11_RS14605 3118923..3119186 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMDB11_RS14610 3119524..3119862 + 339 WP_016926703.1 YegP family protein -
SMDB11_RS14615 3120041..3121393 + 1353 WP_025303865.1 tRNA 5-hydroxyuridine modification protein YegQ -
SMDB11_RS24710 3121610..3121831 - 222 WP_141998673.1 hypothetical protein -
SMDB11_RS14620 3121861..3122766 + 906 WP_025303866.1 lipid kinase YegS -
SMDB11_RS14625 3122935..3124149 + 1215 WP_025303867.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14351.67 Da        Isoelectric Point: 9.5570

>T284998 WP_025303864.1 NZ_HG326223:c3118919-3118530 [Serratia marcescens subsp. marcescens Db11]
MYMFDTNTVSHLFRQHPQVLNVMQKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDREAARCYGEM
RANMGRKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT284998 WP_004941563.1 NZ_HG326223:c3119186-3118923 [Serratia marcescens subsp. marcescens Db11]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656VD00

Antitoxin

Source ID Structure

References