Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 850689..851236 Replicon chromosome
Accession NZ_HG326223
Organism Serratia marcescens subsp. marcescens Db11

Toxin (Protein)


Gene name ccdB Uniprot ID A0A380ADA6
Locus tag SMDB11_RS04115 Protein ID WP_025302144.1
Coordinates 850928..851236 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag SMDB11_RS04110 Protein ID WP_025302143.1
Coordinates 850689..850925 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMDB11_RS04095 847175..848710 + 1536 WP_025302140.1 glutathione ABC transporter substrate-binding protein GsiB -
SMDB11_RS04100 848763..849683 + 921 WP_025302141.1 glutathione ABC transporter permease GsiC -
SMDB11_RS04105 849693..850601 + 909 WP_169540348.1 glutathione ABC transporter permease GsiD -
SMDB11_RS04110 850689..850925 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SMDB11_RS04115 850928..851236 + 309 WP_025302144.1 CcdB family protein Toxin
SMDB11_RS04120 851276..852118 - 843 WP_015377214.1 S-formylglutathione hydrolase -
SMDB11_RS04125 852133..853257 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
SMDB11_RS04130 853287..854207 - 921 WP_025302145.1 LysR family transcriptional regulator -
SMDB11_RS04135 854313..855470 + 1158 WP_025302146.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11504.32 Da        Isoelectric Point: 5.0196

>T284990 WP_025302144.1 NZ_HG326223:850928-851236 [Serratia marcescens subsp. marcescens Db11]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT284990 WP_025302143.1 NZ_HG326223:850689-850925 [Serratia marcescens subsp. marcescens Db11]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380ADA6

Antitoxin

Source ID Structure

References