Detailed information of TA system TA284981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5920718..5921292
• Replicon: chromosome
• Accession: NZ_HG322949
• Organism: Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GJA_RS26970
• Protein ID: WP_081905584.1
• Coordinates: 5920718..5920900 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: W0VEJ6
• Locus tag: GJA_RS25705
• Protein ID: WP_038498072.1
• Coordinates: 5920909..5921292 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJA_RS26400	5916979..5917576	+	598	Protein_5122	type VI secretion system tip protein VgrG	-
GJA_RS26405	5917613..5918710	+	1098	Protein_5123	type VI secretion system Vgr family protein	-
GJA_RS25700	5919193..5919366	+	174	Protein_5124	transposase domain-containing protein	-
GJA_RS27635	5919856..5920257	+	402	WP_144241646.1	hypothetical protein	-
GJA_RS26970	5920718..5920900	+	183	WP_081905584.1	type II toxin-antitoxin system HicA family toxin	Toxin
GJA_RS25705	5920909..5921292	+	384	WP_038498072.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GJA_RS25720	5923079..5923750	+	672	Protein_5128	IS66 family transposase	-
GJA_RS27645	5923950..5924349	+	400	Protein_5129	type VI secretion system tip protein VgrG	-
GJA_RS25730	5924362..5924892	-	531	WP_038498083.1	hypothetical protein	-
GJA_RS25735	5924953..5925459	+	507	WP_038498086.1	DUF2875 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5904777..5945179	40402
	-	inside	IScluster/Tn	-	-	5919181..5923774	4593

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-121)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6713.77 Da
• Isoelectric Point: 10.9132

>T284981 WP_081905584.1 NZ_HG322949:5920718-5920900 [Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628]
MNSADIIKQLKSDGWEHVSTRGSHHKYRNPKTGKSVIVPHPKKDLPIGTVNSILKQAQLK

Nucleotide

• Length: 183 bp

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14130.97 Da
• Isoelectric Point: 4.6647

>AT284981 WP_038498072.1 NZ_HG322949:5920909-5921292 [Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628]
MLYPLYVWKDANSAYGASFPDLPGVNTAADELHDLSKAAQEAVEVMYDRETNIPAASAIEKWTSNPDYADGFWMLVNIDL
SKVNTKPVRLNISLPESLLRDIDQFAKSHHLTRSGFLAQAAMRAMAE

Nucleotide

• Length: 384 bp

Structures

Antitoxin

• AlphaFold DB: W0VEJ6