Detailed information of TA system TA028498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 8236222..8236892
• Replicon: chromosome
• Accession: NC_019678
• Organism: Rivularia sp. PCC 7116

Toxin (Protein)

• Gene name: vapB
• Uniprot ID: K9RNL2
• Locus tag: RIV7116_RS31505
• Protein ID: WP_015122393.1
• Coordinates: 8236473..8236892 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: K9RN14
• Locus tag: RIV7116_RS31500
• Protein ID: WP_015122392.1
• Coordinates: 8236222..8236476 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RIV7116_RS31485	8231241..8232068	-	828	WP_015122389.1	alpha/beta hydrolase	-
RIV7116_RS31490	8232413..8233303	+	891	WP_015122390.1	LysR family transcriptional regulator	-
RIV7116_RS31495	8233522..8235795	-	2274	WP_015122391.1	hypothetical protein	-
RIV7116_RS31500	8236222..8236476	+	255	WP_015122392.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RIV7116_RS31505	8236473..8236892	+	420	WP_015122393.1	type II toxin-antitoxin system VapC family toxin	Toxin
RIV7116_RS31515	8237846..8241286	-	3441	WP_015122395.1	virulence factor SrfB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-67)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16010.70 Da
• Isoelectric Point: 5.2702

>T28498 WP_015122393.1 NC_019678:8236473-8236892 [Rivularia sp. PCC 7116]
MKYLLDTCVIYELVAKKPSKKVIDWIDNIEQENIYLSVITIGEIRKGIEKLPESKRKTNLQQWLNDELLIRFQGKILVID
TDVILVWGELTGRLDIEGKRMPAIDSLIAAIAIHNNCSLVTRNEYDFKDVGLSIVNPWQ

Nucleotide

• Length: 420 bp

>T28498 NC_019678:8236473-8236892 [Rivularia sp. PCC 7116]
ATGAAATATCTGCTCGATACCTGTGTAATTTATGAATTAGTAGCAAAAAAACCTTCCAAAAAAGTTATTGATTGGATTGA
TAATATTGAGCAAGAAAATATTTATTTGAGCGTTATTACTATTGGTGAAATTCGTAAGGGAATAGAGAAACTACCCGAAT
CAAAGCGAAAAACGAATCTTCAACAATGGCTAAACGATGAGTTACTAATACGCTTTCAAGGCAAAATATTGGTAATAGAT
ACAGATGTAATCTTGGTTTGGGGAGAATTAACCGGAAGACTCGATATAGAAGGAAAAAGAATGCCTGCAATTGATTCTTT
AATCGCTGCAATTGCGATACACAATAATTGTAGCTTGGTAACTAGAAATGAATATGATTTTAAGGATGTCGGCTTGAGTA
TTGTTAATCCTTGGCAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9832.14 Da
• Isoelectric Point: 4.7174

>AT28498 WP_015122392.1 NC_019678:8236222-8236476 [Rivularia sp. PCC 7116]
MEKYWQLQEAKNKFSEVVDKAINEGAQVITRRGVEVAIVVSYTEYRQMIASKKKISEFFRESPLVEEDLDFSRDKSDARE
DIVL

Nucleotide

• Length: 255 bp

>AT28498 NC_019678:8236222-8236476 [Rivularia sp. PCC 7116]
ATGGAAAAATATTGGCAGCTACAAGAAGCAAAGAATAAATTTAGTGAAGTGGTAGATAAGGCTATCAATGAAGGAGCACA
AGTTATTACTAGAAGGGGTGTTGAAGTCGCAATAGTTGTATCATATACAGAGTATCGTCAGATGATAGCCTCAAAAAAGA
AGATTTCCGAGTTTTTTCGCGAGTCTCCTTTAGTTGAAGAAGATTTAGATTTTAGTAGGGATAAGAGCGATGCTCGGGAA
GATATTGTATTATGA

Structures

Toxin

• AlphaFold DB: K9RNL2

Antitoxin

• AlphaFold DB: K9RN14