Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1487924..1488536 Replicon chromosome
Accession NZ_HG316453
Organism Streptococcus pyogenes strain H293

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag SPYH293_RS07245 Protein ID WP_002994716.1
Coordinates 1488201..1488536 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag SPYH293_RS07240 Protein ID WP_002988079.1
Coordinates 1487924..1488211 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPYH293_RS07215 1483103..1484086 - 984 WP_031488719.1 tagatose-bisphosphate aldolase -
SPYH293_RS07220 1484090..1485019 - 930 WP_031488720.1 tagatose-6-phosphate kinase -
SPYH293_RS07225 1485067..1485582 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
SPYH293_RS07230 1485617..1486045 - 429 WP_014635709.1 galactose-6-phosphate isomerase subunit LacA -
SPYH293_RS07235 1486490..1487263 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
SPYH293_RS07240 1487924..1488211 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
SPYH293_RS07245 1488201..1488536 + 336 WP_002994716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPYH293_RS08935 1488688..1489158 + 471 WP_021733374.1 site-specific integrase -
SPYH293_RS08940 1489121..1489669 + 549 WP_180372715.1 site-specific integrase -
SPYH293_RS07255 1489801..1490193 - 393 WP_002982716.1 30S ribosomal protein S9 -
SPYH293_RS07260 1490214..1490660 - 447 WP_002982710.1 50S ribosomal protein L13 -
SPYH293_RS07265 1490878..1491084 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
SPYH293_RS07270 1491081..1491587 - 507 WP_002988070.1 hypothetical protein -
SPYH293_RS07275 1491723..1492583 - 861 WP_011529009.1 DegV family protein -
SPYH293_RS07280 1492680..1493198 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13154.89 Da        Isoelectric Point: 5.6157

>T284977 WP_002994716.1 NZ_HG316453:1488201-1488536 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT284977 WP_002988079.1 NZ_HG316453:1487924-1488211 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References