Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5079218..5079813 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HUS2011_RS26430 Protein ID WP_000239579.1
Coordinates 5079463..5079813 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HUS2011_RS26425 Protein ID WP_001223208.1
Coordinates 5079218..5079469 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS26415 5074883..5078662 + 3780 WP_000060946.1 autotransporter assembly complex protein TamB -
HUS2011_RS26420 5078665..5079006 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HUS2011_RS26425 5079218..5079469 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HUS2011_RS26430 5079463..5079813 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HUS2011_RS26435 5079893..5080423 - 531 WP_000055072.1 inorganic diphosphatase -
HUS2011_RS26440 5080733..5081689 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HUS2011_RS26445 5081999..5083501 + 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
HUS2011_RS26450 5083515..5084537 + 1023 WP_001387274.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T284974 WP_000239579.1 NZ_HF572917:5079463-5079813 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT284974 WP_001223208.1 NZ_HF572917:5079218-5079469 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References