Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4933028..4933525 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag HUS2011_RS25665 Protein ID WP_001173343.1
Coordinates 4933352..4933525 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag HUS2011_RS25660 Protein ID WP_000398619.1
Coordinates 4933028..4933324 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS25635 4929759..4930478 - 720 WP_000611288.1 two-component system response regulator DcuR -
HUS2011_RS25640 4930475..4932106 - 1632 WP_001216486.1 sensor histidine kinase -
HUS2011_RS25645 4932287..4932517 + 231 WP_000371700.1 (4Fe-4S)-binding protein -
HUS2011_RS25650 4932529..4932801 + 273 WP_000405647.1 N-acetyltransferase -
HUS2011_RS25660 4933028..4933324 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
HUS2011_RS25665 4933352..4933525 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
HUS2011_RS25670 4933644..4935161 - 1518 WP_001295074.1 lysine--tRNA ligase -
HUS2011_RS25675 4935398..4936855 - 1458 WP_000856837.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T284972 WP_001173343.1 NZ_HF572917:4933352-4933525 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT284972 WP_000398619.1 NZ_HF572917:4933028-4933324 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References