Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3566164..3566601 Replicon chromosome
Accession NC_019678
Organism Rivularia sp. PCC 7116

Toxin (Protein)


Gene name hicA Uniprot ID K9RDI5
Locus tag RIV7116_RS13960 Protein ID WP_015118948.1
Coordinates 3566377..3566601 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID K9RD35
Locus tag RIV7116_RS13955 Protein ID WP_015118947.1
Coordinates 3566164..3566373 (+) Length 70 a.a.

Genomic Context

RIV7116_RS13940RIV7116_RS13950RIV7116_RS13955RIV7116_RS13960RIV7116_RS13965RIV7116_RS13970RIV7116_RS34935RIV7116_RS13975RIV7116_RS13935RIV7116_RS13945RIV7116_RS13980RIV7116_RS13985
Location: 3562656..3563285 (630 bp)
Type: Others
Protein ID: WP_015118944.1
Location: 3565939..3566121 (183 bp)
Type: Others
Protein ID: WP_198287589.1
Location: 3566164..3566373 (210 bp)
Type: Antitoxin
Protein ID: WP_015118947.1
Location: 3566377..3566601 (225 bp)
Type: Toxin
Protein ID: WP_015118948.1
Location: 3566703..3566972 (270 bp)
Type: Others
Protein ID: WP_015118949.1
Location: 3567138..3567362 (225 bp)
Type: Others
Protein ID: WP_044290941.1
Location: 3567391..3567699 (309 bp)
Type: Others
Protein ID: WP_015118950.1
Location: 3567812..3568270 (459 bp)
Type: Others
Protein ID: WP_015118951.1
Location: 3561299..3562153 (855 bp)
Type: Others
Protein ID: WP_015118943.1
Location: 3563438..3565648 (2211 bp)
Type: Others
Protein ID: WP_015118945.1
Location: 3568510..3569664 (1155 bp)
Type: Others
Protein ID: WP_015118952.1
Location: 3570290..3570709 (420 bp)
Type: Others
Protein ID: WP_015117032.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RIV7116_RS139353561299..3562153-855WP_015118943.1MerR family transcriptional regulator-
RIV7116_RS139403562656..3563285+630WP_015118944.1TetR/AcrR family transcriptional regulator-
RIV7116_RS139453563438..3565648-2211WP_015118945.1phosphoketolase-
RIV7116_RS139503565939..3566121+183WP_198287589.1hypothetical protein-
RIV7116_RS139553566164..3566373+210WP_015118947.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
RIV7116_RS139603566377..3566601+225WP_015118948.1type II toxin-antitoxin system HicA family toxinToxin
RIV7116_RS139653566703..3566972+270WP_015118949.1hypothetical protein-
RIV7116_RS139703567138..3567362+225WP_044290941.1AAA family ATPase-
RIV7116_RS349353567391..3567699+309WP_015118950.1DUF1272 domain-containing protein-
RIV7116_RS139753567812..3568270+459WP_015118951.1DUF4288 domain-containing protein-
RIV7116_RS139803568510..3569664-1155WP_015118952.1threonine aldolase family protein-
RIV7116_RS139853570290..3570709-420WP_015117032.1IS200/IS605 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-63)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-51)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8666.06 Da        Isoelectric Point: 10.4777

>T28497 WP_015118948.1 NC_019678:3566377-3566601 [Rivularia sp. PCC 7116]
MSNIPVLKPQEVVRILEKLGFVEVRQKGSHKQFRHQDARGTTVPFHKGRDISPRLLKQIANDIEFTIEEFLELR

Download         Length: 225 bp

>T28497 NC_019678:3566377-3566601 [Rivularia sp. PCC 7116]
ATGAGCAACATTCCCGTTTTAAAACCACAAGAAGTTGTACGTATTTTAGAAAAACTCGGTTTTGTAGAAGTTCGTCAAAA
AGGTTCGCACAAACAGTTTCGTCATCAAGACGCTAGAGGAACAACTGTTCCGTTTCACAAAGGACGTGATATTTCTCCAA
GACTTTTAAAACAGATAGCCAATGACATTGAATTCACAATTGAAGAATTTTTAGAGTTGCGGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7859.86 Da        Isoelectric Point: 3.9940

>AT28497 WP_015118947.1 NC_019678:3566164-3566373 [Rivularia sp. PCC 7116]
MKIFTAIVEQDSDTNIYVGYVPGFPGAHSQGETLDELRENLREVIEMLLEDERVVFKTDFVGTQQIVVQ

Download         Length: 210 bp

>AT28497 NC_019678:3566164-3566373 [Rivularia sp. PCC 7116]
ATGAAAATCTTCACCGCAATTGTCGAGCAAGATTCTGACACAAATATTTATGTTGGCTATGTTCCTGGATTTCCAGGAGC
GCATTCTCAAGGAGAAACTTTGGACGAATTACGTGAAAATCTCCGTGAAGTAATTGAAATGCTTTTAGAAGATGAAAGAG
TAGTATTCAAGACGGATTTTGTTGGTACCCAACAGATTGTGGTTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBK9RDI5

Antitoxin

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Source
ID
Structure
AlphaFold DBK9RD35

References