Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3566164..3566601 Replicon chromosome
Accession NC_019678
Organism Rivularia sp. PCC 7116

Toxin (Protein)


Gene name hicA Uniprot ID K9RDI5
Locus tag RIV7116_RS13960 Protein ID WP_015118948.1
Coordinates 3566377..3566601 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID K9RD35
Locus tag RIV7116_RS13955 Protein ID WP_015118947.1
Coordinates 3566164..3566373 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RIV7116_RS13935 3561299..3562153 - 855 WP_015118943.1 MerR family transcriptional regulator -
RIV7116_RS13940 3562656..3563285 + 630 WP_015118944.1 TetR/AcrR family transcriptional regulator -
RIV7116_RS13945 3563438..3565648 - 2211 WP_015118945.1 phosphoketolase -
RIV7116_RS13950 3565939..3566121 + 183 WP_198287589.1 hypothetical protein -
RIV7116_RS13955 3566164..3566373 + 210 WP_015118947.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
RIV7116_RS13960 3566377..3566601 + 225 WP_015118948.1 type II toxin-antitoxin system HicA family toxin Toxin
RIV7116_RS13965 3566703..3566972 + 270 WP_015118949.1 hypothetical protein -
RIV7116_RS13970 3567138..3567362 + 225 WP_044290941.1 AAA family ATPase -
RIV7116_RS34935 3567391..3567699 + 309 WP_015118950.1 DUF1272 domain-containing protein -
RIV7116_RS13975 3567812..3568270 + 459 WP_015118951.1 DUF4288 domain-containing protein -
RIV7116_RS13980 3568510..3569664 - 1155 WP_015118952.1 threonine aldolase family protein -
RIV7116_RS13985 3570290..3570709 - 420 WP_015117032.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-63)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-51)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8666.06 Da        Isoelectric Point: 10.4777

>T28497 WP_015118948.1 NC_019678:3566377-3566601 [Rivularia sp. PCC 7116]
MSNIPVLKPQEVVRILEKLGFVEVRQKGSHKQFRHQDARGTTVPFHKGRDISPRLLKQIANDIEFTIEEFLELR

Download         Length: 225 bp

>T28497 NC_019678:3566377-3566601 [Rivularia sp. PCC 7116]
ATGAGCAACATTCCCGTTTTAAAACCACAAGAAGTTGTACGTATTTTAGAAAAACTCGGTTTTGTAGAAGTTCGTCAAAA
AGGTTCGCACAAACAGTTTCGTCATCAAGACGCTAGAGGAACAACTGTTCCGTTTCACAAAGGACGTGATATTTCTCCAA
GACTTTTAAAACAGATAGCCAATGACATTGAATTCACAATTGAAGAATTTTTAGAGTTGCGGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7859.86 Da        Isoelectric Point: 3.9940

>AT28497 WP_015118947.1 NC_019678:3566164-3566373 [Rivularia sp. PCC 7116]
MKIFTAIVEQDSDTNIYVGYVPGFPGAHSQGETLDELRENLREVIEMLLEDERVVFKTDFVGTQQIVVQ

Download         Length: 210 bp

>AT28497 NC_019678:3566164-3566373 [Rivularia sp. PCC 7116]
ATGAAAATCTTCACCGCAATTGTCGAGCAAGATTCTGACACAAATATTTATGTTGGCTATGTTCCTGGATTTCCAGGAGC
GCATTCTCAAGGAGAAACTTTGGACGAATTACGTGAAAATCTCCGTGAAGTAATTGAAATGCTTTTAGAAGATGAAAGAG
TAGTATTCAAGACGGATTTTGTTGGTACCCAACAGATTGTGGTTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K9RDI5

Antitoxin

Source ID Structure
AlphaFold DB K9RD35

References