Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3433383..3434037 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag HUS2011_RS18245 Protein ID WP_000244772.1
Coordinates 3433383..3433790 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HUS2011_RS18250 Protein ID WP_000354046.1
Coordinates 3433771..3434037 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS18225 3429340..3431073 - 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -
HUS2011_RS18230 3431079..3431789 - 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUS2011_RS18235 3431814..3432710 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HUS2011_RS18240 3432822..3433343 + 522 WP_001055874.1 flavodoxin FldB -
HUS2011_RS18245 3433383..3433790 - 408 WP_000244772.1 protein YgfX Toxin
HUS2011_RS18250 3433771..3434037 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HUS2011_RS18255 3434280..3435260 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HUS2011_RS18260 3435338..3435997 - 660 WP_000250274.1 hemolysin III family protein -
HUS2011_RS18265 3436161..3436472 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
HUS2011_RS18270 3436517..3437950 + 1434 WP_001387034.1 6-phospho-beta-glucosidase BglA -
HUS2011_RS18275 3438007..3438750 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T284967 WP_000244772.1 NZ_HF572917:c3433790-3433383 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT284967 WP_000354046.1 NZ_HF572917:c3434037-3433771 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References