Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 514352..514970 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HUS2011_RS03420 Protein ID WP_001291435.1
Coordinates 514352..514570 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HUS2011_RS03425 Protein ID WP_000344800.1
Coordinates 514596..514970 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS03390 509642..510214 + 573 WP_000779826.1 lipoprotein -
HUS2011_RS03395 510245..510556 - 312 WP_000409911.1 MGMT family protein -
HUS2011_RS03400 510935..511288 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HUS2011_RS03405 511330..512880 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HUS2011_RS03410 513044..513514 - 471 WP_000136192.1 YlaC family protein -
HUS2011_RS03415 513630..514181 - 552 WP_000102564.1 maltose O-acetyltransferase -
HUS2011_RS03420 514352..514570 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HUS2011_RS03425 514596..514970 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HUS2011_RS03430 515516..518665 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
HUS2011_RS03435 518688..519881 - 1194 WP_001386618.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T284957 WP_001291435.1 NZ_HF572917:c514570-514352 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT284957 WP_000344800.1 NZ_HF572917:c514970-514596 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References