284956

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 480056..480893 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag HUS2011_RS03250 Protein ID WP_000227784.1
Coordinates 480056..480598 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag HUS2011_RS03255 Protein ID WP_001297137.1
Coordinates 480582..480893 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS03230 475595..476506 - 912 WP_000705874.1 2-dehydropantoate 2-reductase -
HUS2011_RS03235 476674..477165 + 492 WP_001138904.1 nucleotide binding protein YajQ -
HUS2011_RS03240 477293..478657 - 1365 WP_001000974.1 MFS transporter -
HUS2011_RS03245 479065..480000 + 936 WP_024174603.1 sel1 repeat family protein -
HUS2011_RS03250 480056..480598 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
HUS2011_RS03255 480582..480893 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
HUS2011_RS03260 481078..481968 - 891 WP_000971336.1 heme o synthase -
HUS2011_RS03265 481980..482309 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
HUS2011_RS03270 482309..482923 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
HUS2011_RS03275 482913..484904 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
HUS2011_RS03280 484926..485873 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T284956 WP_000227784.1 NZ_HF572917:c480598-480056 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT284956 WP_001297137.1 NZ_HF572917:c480893-480582 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References