Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4859836..4860479 Replicon chromosome
Accession NZ_HF571988
Organism Yersinia enterocolitica (type O:5) str. YE53/03 isolate host faecal sample

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag YE5303_RS22540 Protein ID WP_046051923.1
Coordinates 4859836..4860255 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag YE5303_RS22545 Protein ID WP_005161959.1
Coordinates 4860252..4860479 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE5303_RS22520 4855108..4855977 + 870 WP_046051920.1 formate dehydrogenase accessory sulfurtransferase FdhD -
YE5303_RS22525 4856104..4856727 + 624 WP_013650637.1 superoxide dismutase [Mn] -
YE5303_RS22530 4857047..4858996 + 1950 WP_046051921.1 methyl-accepting chemotaxis protein -
YE5303_RS22535 4859075..4859746 + 672 WP_046051922.1 6-N-hydroxylaminopurine resistance protein -
YE5303_RS22540 4859836..4860255 - 420 WP_046051923.1 type II toxin-antitoxin system VapC family toxin Toxin
YE5303_RS22545 4860252..4860479 - 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
YE5303_RS22550 4860611..4860967 - 357 WP_005161962.1 YibL family ribosome-associated protein -
YE5303_RS22555 4861060..4862541 - 1482 WP_046051924.1 PLP-dependent aminotransferase family protein -
YE5303_RS22560 4862685..4863296 + 612 WP_046051925.1 LysE family translocator -
YE5303_RS22565 4863293..4863847 - 555 WP_005161972.1 MltR family transcriptional regulator -
YE5303_RS22570 4863944..4865104 - 1161 WP_046051926.1 mannitol-1-phosphate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15580.20 Da        Isoelectric Point: 9.0596

>T284954 WP_046051923.1 NZ_HF571988:c4860255-4859836 [Yersinia enterocolitica (type O:5) str. YE53/03]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDV
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT284954 WP_005161959.1 NZ_HF571988:c4860479-4860252 [Yersinia enterocolitica (type O:5) str. YE53/03]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References