Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3582582..3583200 Replicon chromosome
Accession NZ_HF571988
Organism Yersinia enterocolitica (type O:5) str. YE53/03 isolate host faecal sample

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YE5303_RS16955 Protein ID WP_002208622.1
Coordinates 3582997..3583200 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6TU35
Locus tag YE5303_RS16950 Protein ID WP_005167670.1
Coordinates 3582582..3582950 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE5303_RS16915 3578245..3578505 + 261 WP_046051448.1 type B 50S ribosomal protein L31 -
YE5303_RS16920 3578521..3578664 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YE5303_RS16925 3578792..3579670 - 879 WP_019082550.1 metal ABC transporter substrate-binding protein -
YE5303_RS16930 3579719..3580576 - 858 WP_005163445.1 metal ABC transporter permease -
YE5303_RS16935 3580573..3581301 - 729 WP_046051449.1 ABC transporter ATP-binding protein -
YE5303_RS16945 3582071..3582424 + 354 WP_046051451.1 hypothetical protein -
YE5303_RS16950 3582582..3582950 + 369 WP_005167670.1 Hha toxicity modulator TomB Antitoxin
YE5303_RS16955 3582997..3583200 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
YE5303_RS16960 3584046..3584351 + 306 WP_046052063.1 MGMT family protein -
YE5303_RS16965 3584403..3584933 - 531 WP_046051452.1 YbaY family lipoprotein -
YE5303_RS16970 3585191..3586054 + 864 WP_046051453.1 acyl-CoA thioesterase II -
YE5303_RS16975 3586274..3587563 - 1290 WP_046052064.1 ammonium transporter AmtB -
YE5303_RS16980 3587603..3587941 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T284951 WP_002208622.1 NZ_HF571988:3582997-3583200 [Yersinia enterocolitica (type O:5) str. YE53/03]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14134.86 Da        Isoelectric Point: 4.4085

>AT284951 WP_005167670.1 NZ_HF571988:3582582-3582950 [Yersinia enterocolitica (type O:5) str. YE53/03]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6L1C1

References