Detailed information of TA system TA284949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2527399..2528359
• Replicon: chromosome
• Accession: NZ_HF571988
• Organism: Yersinia enterocolitica (type O:5) str. YE53/03 isolate host faecal sample

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: YE5303_RS11820
• Protein ID: WP_019079355.1
• Coordinates: 2527901..2528359 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: YE5303_RS11815
• Protein ID: WP_019079356.1
• Coordinates: 2527399..2527845 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE5303_RS11795	2523081..2523788	+	708	WP_046050951.1	murein tripeptide amidase MpaA	-
YE5303_RS11800	2523785..2524756	-	972	WP_019079358.1	L-Ala-D/L-Glu epimerase	-
YE5303_RS11805	2524909..2525412	+	504	WP_005161000.1	thiol peroxidase	-
YE5303_RS11810	2525496..2527079	-	1584	WP_019079357.1	transcriptional regulator TyrR	-
YE5303_RS11815	2527399..2527845	+	447	WP_019079356.1	DUF2384 domain-containing protein	Antitoxin
YE5303_RS11820	2527901..2528359	+	459	WP_019079355.1	RES family NAD+ phosphorylase	Toxin
YE5303_RS11825	2528362..2529426	-	1065	WP_046050952.1	YcjF family protein	-
YE5303_RS11830	2529423..2530820	-	1398	WP_046050953.1	YcjX family protein	-
YE5303_RS11835	2530801..2531040	-	240	WP_005169543.1	phage shock protein PspD	-
YE5303_RS11840	2531086..2531475	-	390	WP_046050954.1	envelope stress response membrane protein PspC	-
YE5303_RS11845	2531475..2531702	-	228	WP_019079351.1	envelope stress response membrane protein PspB	-
YE5303_RS11850	2531931..2532596	-	666	WP_019079350.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17205.62 Da
• Isoelectric Point: 4.6956

>T284949 WP_019079355.1 NZ_HF571988:2527901-2528359 [Yersinia enterocolitica (type O:5) str. YE53/03]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTDWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPRHKSFQACLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16237.66 Da
• Isoelectric Point: 9.1260

>AT284949 WP_019079356.1 NZ_HF571988:2527399-2527845 [Yersinia enterocolitica (type O:5) str. YE53/03]
MRAYHPTPATKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp