Detailed information of TA system TA284944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 1162600..1163965
• Replicon: chromosome
• Accession: NZ_HF571988
• Organism: Yersinia enterocolitica (type O:5) str. YE53/03 isolate host faecal sample

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: YE5303_RS05530
• Protein ID: WP_019083804.1
• Coordinates: 1162988..1163965 (+)
• Length: 326 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: YE5303_RS05525
• Protein ID: WP_046051984.1
• Coordinates: 1162600..1162995 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE5303_RS05495	1157836..1159239	-	1404	WP_019083810.1	hypothetical protein	-
YE5303_RS05500	1159546..1160049	+	504	WP_019083809.1	DUF2569 family protein	-
YE5303_RS05505	1160317..1160877	-	561	WP_019083808.1	hypothetical protein	-
YE5303_RS05510	1161263..1161478	-	216	Protein_1056	hypothetical protein	-
YE5303_RS05520	1162077..1162511	-	435	WP_046050397.1	hypothetical protein	-
YE5303_RS05525	1162600..1162995	+	396	WP_046051984.1	hypothetical protein	Antitoxin
YE5303_RS05530	1162988..1163965	+	978	WP_019083804.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
YE5303_RS05535	1164433..1165521	-	1089	WP_046050398.1	helicase RepA family protein	-
YE5303_RS05540	1165518..1166477	-	960	WP_046050399.1	toprim domain-containing protein	-
YE5303_RS23890	1166470..1167008	-	539	Protein_1062	ash family protein	-
YE5303_RS05555	1167008..1167208	-	201	WP_019082167.1	AlpA family transcriptional regulator	-
YE5303_RS05560	1167211..1168089	-	879	WP_046050402.1	integrase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1157836..1174844	17008

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-298)

Antitoxin

• Protein of unknown function DUF6088 (7-90)

Sequences

Toxin

Protein

• Length: 326 a.a.
• Molecular weight: 37452.99 Da
• Isoelectric Point: 4.9500

>T284944 WP_019083804.1 NZ_HF571988:1162988-1163965 [Yersinia enterocolitica (type O:5) str. YE53/03]
MDKLSMIFADVADALGIGATSIVEKDYYVIELLRLLQPLIFETHQLVFAGGTSLAKSGIKLNRMSEDVDIKLIPNPDFLD
DTHFSRSQRKNTRKEIIEKISDIIIASELFKFDKSYPRIARDEYRYNDIQIQYPQEFTQVPCLRPFIKLELMESDLLEPA
ELRNISSFVYELAGKGSEISAFPCTTIISTQAEKIVAMMRRTAAFMRNVDRKDDESLVRHIYDNYRIVDALGLNICQLSV
FVQQTIQLDIERYGCQHPQLKANAIDELKTGLDEIGSNPYFKERYGQFVVPMVFENSRVEWEEVYHCFRQTALETLKCLD
GSLTK

Nucleotide

• Length: 978 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14812.09 Da
• Isoelectric Point: 10.7908

>AT284944 WP_046051984.1 NZ_HF571988:1162600-1162995 [Yersinia enterocolitica (type O:5) str. YE53/03]
MTIKERIQTRLKRSKRYVFTRDDFKDIADYDQIGRVLRNLVKEGLLLRVGYGLYTKARKNSITGKIMPASPGGSDAVILE
SLDRLNVHYTLDASTTKYIKGETTQVPAYTQVKTSPRFKRALSVGNSRLNG

Nucleotide

• Length: 396 bp