Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 885562..886234 Replicon chromosome
Accession NZ_HF571988
Organism Yersinia enterocolitica (type O:5) str. YE53/03 isolate host faecal sample

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag YE5303_RS04135 Protein ID WP_046050300.1
Coordinates 885809..886234 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag YE5303_RS04130 Protein ID WP_004390965.1
Coordinates 885562..885828 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE5303_RS04105 881533..881970 + 438 WP_019082405.1 lipocalin-like domain-containing protein -
YE5303_RS04110 881986..882735 + 750 WP_019082406.1 SDR family oxidoreductase -
YE5303_RS04115 882748..883350 - 603 WP_011817027.1 HD domain-containing protein -
YE5303_RS04120 883588..884271 + 684 WP_019082407.1 hemolysin III family protein -
YE5303_RS04125 884304..885296 - 993 WP_046050299.1 tRNA-modifying protein YgfZ -
YE5303_RS04130 885562..885828 + 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
YE5303_RS04135 885809..886234 + 426 WP_046050300.1 protein YgfX Toxin
YE5303_RS04140 886234..886932 + 699 WP_011817024.1 two-component system response regulator CreB -
YE5303_RS04145 886943..888370 + 1428 WP_019078986.1 two-component system sensor histidine kinase CreC -
YE5303_RS04150 888462..889883 + 1422 WP_046050301.1 cell envelope integrity protein CreD -
YE5303_RS04155 889955..890473 - 519 WP_019078984.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16452.24 Da        Isoelectric Point: 9.8217

>T284942 WP_046050300.1 NZ_HF571988:885809-886234 [Yersinia enterocolitica (type O:5) str. YE53/03]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSNRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT284942 WP_004390965.1 NZ_HF571988:885562-885828 [Yersinia enterocolitica (type O:5) str. YE53/03]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References